miR-141 and miR-200c as Markers of Overall Survival in Early Stage Non-Small Cell Lung Cancer Adenocarcinoma

Tejero, Rut; Navarro, Alfons; Campayo, Marc; Viñolas, Núria; Marrades, Ramón M.; Cordeiro, Anna; Ruíz-Martínez, Marc; Santasusagna, Sandra; Molins, Laureano; Ramírez, Josep; Monzó, Mariano

doi:10.1371/journal.pone.0101899

Cited by 117 publications

(94 citation statements)

References 36 publications

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“…To the best of our knowledge, there have been only 4 clinical studies on miR-200c expression in NSCLC to date, producing contradictory results (i.e. that miR-200c has been reported to have oncogenic or tumor-suppressive functions) (10,12,22,23). The present study aimed to assess miR-200c expression in NSCLC, and to investigate the role of miR-200c in relation to carcinogenesis and the prognosis of NSCLC patients.…”

Section: Discussionmentioning

confidence: 96%

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Tian

Yue

et al. 2017

Oncology Letters

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Abstract. MicroRNAs (miRNAs/miRs) are a class of small, highly conserved non-coding RNAs that can serve either oncogenic or tumor-suppressive roles in a wide variety of tumors. miR-200c is a member of the miR-200 family whose specific role in non-small cell lung cancer (NSCLC) has not yet been elucidated. The purpose of the present study was to detect the expression level of miR-200c in NSCLC, and to analyze its association with clinicopathological factors and patient prognosis. The present study determined the expression levels of miR-200c in 110 tumor samples collected from patients diagnosed with NSCLC who underwent complete tumor resection with regional lymph node dissection, as assessed by reverse transcription-quantitative polymerase chain reaction. The association between the expression level of miR-200c and clinicopathological features and patient prognosis was also analyzed. The results showed that miR-200c overexpression was detected in 66 of the 110 cases and was significantly associated with positive lymph node metastasis (P<0.001). Univariate survival analysis demonstrated that high miR-200c expression, positive lymph node metastasis and advanced Tumor-Node-Metastasis (TNM) classification stage significantly predicted decreased 5-year disease-free survival rates (all P<0.05) and poor 5-year overall survival rates (all P<0.01), respectively. The results of multivariate Cox regression analysis showed that TNM stage and miR-200c expression retained its significance as an independent prognostic factor for unfavorable 5-year disease-free survival rates (P<0.05) and poor 5-year overall survival rates (P<0.01). The present findings suggest that miR-200c overexpression is significantly associated with poor survival rates in NSCLC and that miR-200c could play an oncogenic role. miR-200c may have clinical potential as a promising prognostic predictor for patients with NSCLC.

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Section: Discussionmentioning

confidence: 96%

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Tian

Yue

et al. 2017

Oncology Letters

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“…Furthermore, it was also shown that the expression level of miR-141 was associated with cancerspecific survival. Tejero et al (2014) found that high miR-141 expression was associated with shorter overall survival in patients with non-small cell lung cancer (NSCLC). Gao and Wu (2015) found that serum miR-141 levels were significantly elevated in epithelial ovarian cancer patients compared to healthy controls, and patients with low miR-141 levels showed a significantly higher rate of survival.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of miR-141 downregulation in gastric cancer

Lü¹,

Hu²,

Sun³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.Previous research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer. In the present study, we investigated the clinical significance and prognostic value of miR-141 in gastric cancer. Paired tissue specimens (tumor and adjacent normal mucosa) from 95 patients with gastric cancer were obtained at the Department of General Surgery, Xiangya Hospital, Central South University from March 2009 to February 2014. The levels of miR-141 in cancerous and corresponding non-cancerous tissues were detected by quantitative reverse transcription-polymerase chain reaction. Associations between clinicopathological parameters and miR-141 expression were evaluated using chi-square tests. Overall survival was calculated and survival curves were plotted using the Kaplan-Meier method; differences between groups were compared using log-rank tests. Compared to the matched normal gastric mucosa, gastric cancer tissues had significantly lower miR-141 expression levels (P < 0.001). This decreased miR-141 expression was significantly associated with tumor differentiation (P = 0.044), positive lymph node metastasis (P = 0.010), distant metastasis (P < 0.001), and advanced tumor-node-metastasis (TNM) stage (P < 0.001). Furthermore, a significant relationship was found between miR-141 expression and overall survival (P = 0.012, log-rank (2015) test). Cox regression analysis revealed that lymph node metastasis (P = 0.003), distant metastasis (P = 0.001), TNM stage (P < 0.001), and miR-141 expression (P = 0.007) were independent prognostic factors in patients with gastric cancer. Our data provide evidence that the downregulation of miR-141 may contribute to the aggressive progression and poor prognosis of human gastric cancer.

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“…Ovarian and breast cancer patients showing incomplete response to paclitaxel treatment expressed low levels of miR-200c along with significant increase in beta-tubulin and ZEB1 expression when compared with patients showing complete response to paclitaxel [109,118]. Furthermore, in NSCLC patients, high expression of miR-200c has been found to be correlated with bigger tumor size and worse overall survival suggesting an oncogenic activity of miR-200c [114,115]. In terms of tumor subtype classification, oncocytoma and chromophobe structures in renal tumors can be distinguished according to miR200c and miR-139-5p expression patterns [121].…”

Section: Mir-200c As a Biomarkermentioning

confidence: 99%

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

et al. 2016

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MicroRNAs (miRNAs) are 20-22-nucleotide small endogenous non-coding RNAs which regulate gene expression at post-transcriptional level. In the last two decades, identification of almost 2600 miRNAs in human and their potential to be modulated opened a new avenue to target almost all hallmarks of cancer. miRNAs have been classified as tumor suppressors or oncogenes depending on the phenotype they induce, the targets they modulate, and the tissue where they function. miR-200c, an illustrious tumor suppressor, is one of the highly studied miRNAs in terms of development, stemness, proliferation, epithelial-mesenchymal transition (EMT), therapy resistance, and metastasis. In this review, we first focus on the regulation of miR-200c expression and its role in regulating EMT in a ZEB1/E-cadherin axis-dependent and ZEB1/E-cadherin axis-independent manner. We then describe the role of miR-200c in therapy resistance in terms of multidrug resistance, chemoresistance, targeted therapy resistance, and radiotherapy resistance in various cancer types. We highlight the importance of miR-200c at the intersection of EMT and chemoresistance. Furthermore, we show how miR-200c coordinates several important signaling cascades such as TGF-β signaling, PI3K/Akt signaling, Notch signaling, VEGF signaling, and NF-κB signaling. Finally, we discuss miR-200c as a potential prognostic/diagnostic biomarker in several diseases, but mainly focusing on cancer and its potential application in future therapeutics.

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miR-141 and miR-200c as Markers of Overall Survival in Early Stage Non-Small Cell Lung Cancer Adenocarcinoma

Cited by 117 publications

References 36 publications

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer

Prognostic value of miR-141 downregulation in gastric cancer

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

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