Prognostic value of miR-141 downregulation in gastric cancer

Lü, Yan; Hu, Jiong; Sun, Wenjie; Duan, Xin; Chen, X

doi:10.4238/2015.december.16.31

Cited by 22 publications

(12 citation statements)

References 17 publications

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“…He et al reported that miR-141 as a tumor-suppressor and miR-141 overexpression could suppress proliferation but induced apoptosis through down-regulating H19 or miR-675 in osteosarcoma [12]. Besides, miR-141 also served as a tumor suppressor in nasopharyngeal carcinoma [13], hepatocellular carcinoma [14], and gastric cancer [15]. …”

Section: Introductionmentioning

confidence: 99%

LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141

et al. 2017

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BackgroundLncRNA small nucleolar RNA host gene 15 (SNHG15) was reported to play an oncogenic role in tumors. However, the role of SNHG15 and its molecular mechanism in osteosarcoma (OS) cells are largely unknown.MethodsqRT-PCR was performed to evaluate the expression levels of SNHG15 and miR-141 in OS tissues and cells. Cell transfection with different siRNAs, miRNAs or pcDNAs into U2OS and MG63 cells were carried out by Lipofectamine 2000. The effects of SNHG15 and miR-141 on OS cell proliferation, invasion and the levels of autophagy-related proteins were analyzed by MTT assay, Transwell invasion/migration assay and western blot, respectively. Luciferase reporter assay was used to confirm whether SNHG15 could directly interact with miR-141.ResultsWe found that up-regulation of SNHG15 was inversely correlated with miR-141 expression in OS tissues. SNHG15 knockdown and miR-141 overexpression significantly suppressed cell proliferation, invasion, migration and autophagy while SNHG15 overexpression and miR-141 repression exhibited the opposite effects on OS cells. Besides, SNHG15 could directly interact with miR-141 and regulate its expression. Furthermore, miR-141 suppressing significantly overturned the inhibition on proliferation, invasion, migration and autophagy mediated by SNHG15 knockdown while miR-141 overexpression remarkably attenuated SNHG15 overexpression-induced proliferation, invasion, migration and autophagy in OS cells.ConclusionOur data showed that SNHG15 contributes to proliferation, invasion, migration and autophagy in OS by negatively regulating miR-141, providing a new potential target and prognostic biomarker for the treatment of OS.

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Section: Introductionmentioning

confidence: 99%

LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141

et al. 2017

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“…These finding suggest that the miR-200 family members function as tumor suppressor genes. The tumor-suppressive roles of the miR-200 family have also been reported in gastric [8], breast [9], endometrial, [10] pancreatic cancers [11, 12], hepatocellular carcinoma [13], gliomas [14], and lung cancer [15, 16]. …”

Section: Introductionmentioning

confidence: 99%

Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis

Lee

Ahn

Won

et al. 2017

BioMed Research International

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Background/Aims. The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition. However, the potential prognostic value of miR-200s in various human malignancies remains controversial. This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors. Methods. Eligible published studies were identified by searching the Embase, PubMed, CINAHL, and Google scholar databases. Patient clinical data were pooled, and pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to calculate the strength of this association. Results. The pooled HRs suggested that high tissue expression of miR-200 family members was associated with better survival (overall survival [OS]: HR = 0.70, 95% CI 0.54–0.91; progression-free survival [PFS]: HR = 0.63, 95% CI 0.52–0.76) in thirty-four eligible articles. In contrast, higher expression of circulating miR-200 members was significantly associated with poor clinical outcome (OS, HR = 1.68, 95% CI 1.15–2.46; PFS, HR = 2.62, 95% CI 1.68–4.07). Conclusion. The results from this meta-analysis suggest that miR-200 family members are potential prognostic biomarkers in patients with various carcinomas. To apply these findings in the clinic, large prospective studies are needed to validate the prognostic values of miR-200s in individual cancer types.

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“…These results indicate that hsa-miR-429 plays different (even opposite) roles in tumorigenesis and cancer progression in different tumors. Hsa-miR-141 is aslo an important member in the miR-200 family, several previous studies have shown that has-miR-141 was involved in prognosis of cancer [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Investigation of candidate biomarkers and prognostic values in endometrial cancer based on bioinformatics analysis

2019

Preprint

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Background: Endometrial cancer is a common gynecological cancer whose incidence is increasing annually worldwide. However, the biomarkers that provide the prognosis and progression of endometrial cancer are still lacking. Methods: The differentially expressed mRNAs and miRNAs were screened out using mRNA and miRNA expression data of endometrial cancer from Gene Expression Omnibus, and then validated in the Cancer Genome Atlas. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted using the Database for Annotation,Visualization and Integrated Discovery. A protein–protein interaction network was constructed by STRING and visualized using Cytoscape. OncoLnc was used for studying the prognostic effects of the hub genes. In addition, miRecords were used to predict target genes of differentially expressed miRNAs, and then a miRNA-mRNA regulatory network was constructed. Results: Two eligible human endometrial cancer datasets ( GSE17025 and GSE25405) met the requirement. A total of 520 differentially expressed mRNAs and 30 differentially expressed miRNAs were identified. These differentially expressed mRNAs were mainly enriched in cell cycle, skeletal system development, vasculature development, oocyte maturation, and oocyte meiosis signaling pathways. 160 pairs of differentially expressed miRNAs and mRNAs, including 22 differentially expressed miRNAs and 71 overlapping differentially expressed mRNAs, were validated in endometrial cancer samples using starBase v2.0 project. And the prognosis analysis found that Cyclin E1 (CCNE1, one of the 82 hub genes, which was correlated with hsa-miR-195) was correlated with significantly worse overall survival in endometrial cancer patients. Conclusions: These hub genes and differentially expressed miRNAs might be used as molecular targets for the treatment of endometrial cancer and prognostic biomarkers for endometrial cancer.

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Prognostic value of miR-141 downregulation in gastric cancer

Cited by 22 publications

References 17 publications

LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141

LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141

Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis

Investigation of candidate biomarkers and prognostic values in endometrial cancer based on bioinformatics analysis

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