MiR-17-92 cluster and immunity

Kuo, George; Wu, Chao‐Yi; Yang, Huang‐Yu

doi:10.1016/j.jfma.2018.04.013

Cited by 79 publications

(59 citation statements)

References 53 publications

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“…The miR-17-92 cluster, which is essential for the differentiation of immune cells, is highly expressed in EBV-positive tumors, such as NPC (41) and DLBCL (42). High expression of miR-17-92 in B cells, T cells, NK cells, macrophages, and dendritic cells is known to inhibit cellular differentiation and function (43).…”

Section: Host Mirna-mediated Evasion Of the Immune System By Ebv-infementioning

confidence: 99%

Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases

et al. 2020

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Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregulated upon EBV infection. Viral and host miRNAs are important in maintaining viral infection and evasion of host immunity. Although miRNAs in EBV-infected cells often promote cell proliferation by targeting apoptosis or cell cycle, this review focuses on the regulation of the recognition of the host immune system. This review firstly describes the location and organization of two clusters of viral miRNAs, then describes evasion from host immune surveillance systems by modulating viral gene expression or inhibiting innate and acquired immunity by viral miRNAs as well as host miRNAs. Another topic is the enigmatic depletion of viral miRNAs in several types of EBV-infected tumor cells. Finally, this review introduces the strong correlation of nasopharyngeal cancer cases with a newly identified single nucleotide polymorphism that enhances BART miRNA promoter activity.

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Section: Host Mirna-mediated Evasion Of the Immune System By Ebv-infementioning

confidence: 99%

Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases

et al. 2020

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“…It also found that higher levels of miR‐17‐92 contribute to inhibition of tumor growth and metastasis in a mouse tumor model (Jiang et al, ). Recent research identified that the miR‐17‐92 cluster was a crucial player in the development of the immune system (Kuo, Wu, & Yang, ). Previous study indicated that MIR17HG copy numbers would seem to be related to response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer (Molinari et al, ).…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population

Chen

Bai

Yue-min

et al. 2019

Molec Gen & Gen Med

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Background Colorectal cancer is the third most common cancer worldwide. Recently, an increasing number of evidences suggest that genetic susceptibility plays an important role in the occurrence of colorectal cancer. This study aimed to better understand the influence of MIR17HG polymorphisms on colorectal cancer susceptibility in the Chinese Han population. Methods We recruited 514 patients with colorectal cancer and 510 healthy controls to investigate the association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population. Genotyping was performed with the Agena MassARRAY platform. We used the χ2 test to compare the distributions of single nucleotide polymorphisms (SNPs) allele and genotypes frequencies between cases and controls. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate the association under genetic models. Linkage disequilibrium between the five SNPs was assessed using the Haploview software. Results Overall analysis found that rs7336610 and rs1428 and haplotype CTAGA were significantly associated with increased risk of colorectal cancer. However, we found rs7318578 was associated with a decreased risk of colorectal cancer in the dominant model. Stratification analysis showed that rs7336610, rs7318578, and rs1428 were also associated with rectal cancer risk. Gender stratification analysis found that rs7336610, rs7318578, rs17735387, and rs1428 were significantly associated with colorectal cancer risk in males. Conclusion In conclusion, this study indicated that the polymorphisms of MIR17HG were associated with colorectal cancer risk. Therefore, our findings may provide new insights into the development of colorectal cancer. Further association and functional studies are of great importance to confirm these results and to define the potential biological mechanism of colorectal cancer.

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“…It was found that the miR-17-92 cluster's increasing role in regulating the immune system is involved in innate and adaptive immunity, including B cells and subsets of T cells such as Th1, Th2, T follicular helper cells, regulatory T cells, monocytes/macrophages, NK cells, and dendritic cells [46]. Moreover, the study found that the miR-17 approximately 92 cluster is a critical regulator of T cell-dependent antibody responses and follicular helper T cells' (TFH cells) differentiation [47].…”

Section: T Cell Follicular Helper T Cells (Tfh Cells) and Th17mentioning

confidence: 99%

“…B cells play a critical role in immune responses, but the regulation of microRNAs to B-cell proliferation and function was partially understood. Not only miR-17-92 cluster was involved in B cell [46], but miR-146a also enhances class switch and secretion of IgE in B cells [53]. As an important immune regulatory cell, thrombospondin 1 (TSP1)-producing B cells were regulated by miRNAs as well.…”

Section: Mirna Regulates B Cellmentioning

confidence: 99%

Pathogenic Roles of MicroRNA in the Development of Asthma

Dong¹,

Zhong²

2019

Asthma - Biological Evidences

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Asthma is a common and chronic inflammatory disease. Pathogenic mechanism underlying asthma is complicated. The inflammatory reactions in asthma have been recognized to involve mast cells, eosinophils, lymphocytes (T cells, B cells), macrophages, and dendritic cells. MicroRNA (miRNA, miR) is a group of small noncoding RNAs with 21-25 nucleotides (nt) in length, which impact biologic responses through the regulation of mRNA transcription and/or translation. MicroRNAs are related to developmental processes of many immunologic diseases. Most studies showed that regulation of miRNAs to their targeting genes appears to play an important role in the development of asthma. This chapter has discussed altered expression of miRNAs in cells and tissues from patients with asthma, in order to better understand the mechanics of pathogenesis of asthma. In addition, the regulation of miRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action.

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MiR-17-92 cluster and immunity

Cited by 79 publications

References 53 publications

Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases

Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases

Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population

Pathogenic Roles of MicroRNA in the Development of Asthma

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