MiR-25 and KLF4 relationship has early prognostic significance in the development of cervical cancer

Polat, Aysegul Yucel; Ayva, Ebru Sebnem; Gürdal, Hakan; Özdemir, Binnaz Handan; Dedeoğlu, Bala Gür

doi:10.1016/j.prp.2021.153435

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…The participation of Klf4 is ambiguous in cancer. In cervical cancer, it has been reported as reduced [136], while in breast cancer, Klf4 expression was overexpressed [137]. The participation of several genes, proteins, and miRNAs should be explored in detail, leading to a deeper understanding of the mechanisms implicated that could represent therapeutic targets for the treatment of inflammation-related diseases.…”

Section: Adipose Tissue Dysregulation In Obesity Can Potentiate Cance...mentioning

confidence: 99%

“…Genes of lncRNAs carry introns and exons and perform RNA maturation processes similar to those of mRNAs, such as conventional and alternative splicing; however, they have also been reported to have different transcription and processing pathways, among others, which could be related to the various cellular targets and activities in which they are involved [14,146]. LncRNAs regulate gene expression by interacting with nucleic acids and proteins in diverse cellular processes [134][135][136]. It has also been reported that lncR-NAs may also be involved in the regulation of cancer progression, as well as in other diseases [147,148].…”

Section: Biogenesis Of Lncrnasmentioning

confidence: 99%

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miRNAs as Interconnectors between Obesity and Cancer

González-Sánchez,

Granados-López,

López-Hernández

et al. 2024

ncRNA

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Obesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss miRNAs and lncRNAs dysregulation involved in obesity and some cancers, shedding light on how these conditions may exacerbate one another through the dysregulation of ncRNAs. lncRNAs have been reported as regulating microRNAs. An in silico investigation of lncRNA and miRNA interplay is presented. Our investigation revealed 44 upregulated and 49 downregulated lncRNAs in obesity and cancer, respectively. miR-375, miR-494-3p, miR-1908, and miR-196 were found interacting with 1, 4, 4 and 4 lncRNAs, respectively, which are involved in PPARγ cell signaling regulation. Additionally, miR-130 was found to be downregulated in obesity and reported as modulating 5 lncRNAs controlling PPARγ cell signaling. Similarly, miR-128-3p and miR-143 were found to be downregulated in obesity and cancer, interacting with 5 and 4 lncRNAs, respectively, associated with MAPK cell signaling modulation. The delicate balance between miRNA and lncRNA expression emerges as a critical determinant in the development of obesity-associated cancers, presenting these molecules as promising biomarkers. However, additional and deeper studies are needed to reach solid conclusions about obesity and cancer connection by ncRNAs.

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Section: Adipose Tissue Dysregulation In Obesity Can Potentiate Cance...mentioning

confidence: 99%