Recent strategies for electrochemical sensing detection of miRNAs in lung cancer

Recent advancement in the detection of potential cancer biomarkers using the nanomaterial integrated electrochemical sensing technique: a detailed review

“…100 Similarly, FB can be helpful in the evaluation of a patient who is suspected of having lung cancer, but its sensitivity is constrained by the location and size of the lesion. 101 As the most popular approach for identifying lung cancer, computed tomography (CT) has proven to be far more effective than chest radiography. 102 CT screening, however, has not been regarded as a cost-effective method because there is still room for improvement in terms of performance.…”

“…The typical properties of microRNAs include high sequence similarity, low melting points, and short sequences. 101 Because of this, high sensitivity detection of microRNAs using conventional sandwich structure DNA probes and single strand DNA probes is difficult. On the other side, single-base mismatch nucleic acid detection has been effectively accomplished using DNA probes with a stem-loop structure.…”