MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer

Chan, John K.; Kiet, T.; Blansit, Kevin; Ramasubbaiah, Rashmi; Hilton, Joan F.; Kapp, Daniel S.; Matei, Daniela

doi:10.1016/j.ygyno.2014.03.564

Cited by 70 publications

(48 citation statements)

References 35 publications

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“…Previous studies have demonstrated that miRNAs are able to regulate angiogenesis and tumor cell survival (47)(48)(49)(50)(51). The miR-17-92 cluster is significantly upregulated in Myc-induced tumors and overexpressed in Ras cells, where it enhances tumor vessel growth in a paracrine manner (47), exhibiting potent tumor angiogenesis-promoting activity.…”

Section: Angiogenesismentioning

confidence: 99%

“…The miR-17-92 cluster is significantly upregulated in Myc-induced tumors and overexpressed in Ras cells, where it enhances tumor vessel growth in a paracrine manner (47), exhibiting potent tumor angiogenesis-promoting activity. In ovarian cancer, miR-378 enhances tumor angiogenesis, tumor cell survival and growth by targeting ALCAM and EHD1 (48). The overexpression of let-7f and miR-27b exerts pro-angiogenic effects, as shown by the blockade of angiogenesis with 20-O-methyl oligonucleotide inhibitors in vitro (49).…”

Section: Angiogenesismentioning

confidence: 99%

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MicroRNAs and cancer: Key paradigms in molecular therapy (Review)

et al. 2017

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Abstract. MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that performs an important role in post-transcriptional gene regulation. Since miRNAs were first identified in 1993, a number of studies have demonstrated that they act as tumor suppressors or oncogenes in human cancer, including colorectal, lung, brain, breast and liver cancer, and leukemia. Large high-throughput studies have previously revealed that miRNA profiling is critical for the diagnosis and prognosis of patients with cancer, while certain miRNAs possess the potential to be used as diagnostic and prognostic biomarkers or therapeutic targets in cancer. The present study reviews the studies and examines the roles of miRNAs in cancer diagnosis, prognosis and treatment, and discusses the potential therapeutic modality of exploiting miRNAs.

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Section: Angiogenesismentioning

confidence: 99%

Section: Angiogenesismentioning

confidence: 99%

MicroRNAs and cancer: Key paradigms in molecular therapy (Review)

et al. 2017

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“…We found that approximately 1.3% of the predicted miRNA targets formed reciprocal "up-down" or "down-up" expression relationships with miRNAs, suggesting that the modulation of miRNA-mRNA interactions could be promising biomarkers for cancers. Integrated expression analysis of miRNAs and mRNAs using microarray technology have revealed signatures implicated in ovarian cancer [165,166] , breast cancer [167][168][169][170][171] , metastatic osteosarcoma [172] , gastric cancer [173,174] , pancreatic cancer [175] , oral squamous cell carcinoma [176] , lung cancer [177][178][179] , prostate cancer [180,181] , follicular thyroid tumors [182] , retinoblastoma [183] , etc. The miRNA/mRNA interactome not only includes the interactions between an miRNA and its targets but also comprises the TF-miRNA network.…”

Section: Integrated Analysis Of Mirnas and Mrnas In Cancermentioning

confidence: 99%

Genome-wide analysis of microRNA and mRNA expression signatures in cancer

Xiao

2015

Acta Pharmacol Sin

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Cancer is an extremely diverse and complex disease that results from various genetic and epigenetic changes such as DNA copy-number variations, mutations, and aberrant mRNA and/or protein expression caused by abnormal transcriptional regulation. The expression profiles of certain microRNAs (miRNAs) and messenger RNAs (mRNAs) are closely related to cancer progression stages. In the past few decades, DNA microarray and next-generation sequencing techniques have been widely applied to identify miRNA and mRNA signatures for cancers on a genome-wide scale and have provided meaningful insights into cancer diagnosis, prognosis and personalized medicine. In this review, we summarize the progress in genome-wide analysis of miRNAs and mRNAs as cancer biomarkers, highlighting their diagnostic and prognostic roles.

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“…miRNAs have been implicated in chemoresistance of OC, and several studies have addressed this issue [65][66][67][68][69][70][71][72][73][74][75][76][77][78][79] (Table 3). miR-182 has been shown to reduce chemosensitivity to cisplatin and paclitaxel by negatively regulating the tumor [70], which plays an important role in the initiation and progression of OC [80].…”

Section: Mirnas As Potential Predictive and Prognostic Markersmentioning

confidence: 99%

“…miR-484 targets vascular endothelial growth factor (VEGF) signaling pathways by either directly modulating VEGFB protein on carcinoma cells or interfering with the receptor VEGFR2 in the tumor-associated endothelial cells. miR-378, which targets ALCAM, EHD1, TLN1 and ELK3, was identified as a potential biomarker for response to anti-angiogenic treatment and independent predictor for PFS [76].…”

Section: Mirnas As Potential Predictive and Prognostic Markersmentioning

confidence: 99%