Mir‐483 inhibits colon cancer cell proliferation and migration by targeting TRAF1

Niu, Zi-Yu; Li, Wenli; Jiang, Dalei; Li, Yansong; Xie, Xin

doi:10.1016/j.kjms.2018.04.005

Cited by 19 publications

(17 citation statements)

References 27 publications

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“…MiR-483-3p is underexpressed in breast cancer [28, 29], colon cancer [30], and gastric cancer [30]. In our study, we also demonstrated that miR-483-3p is downregulated in OS tissues and cell lines.…”

Section: Discussionsupporting

confidence: 72%

“…After screening for miRNAs using the online software starBase 3.0, miR-483-3p was predicted to be a potential target of NR2F1-AS1 (Figure 3B). MiR-483-3p was chosen for further experimental validation because of its known tumor-suppressive actions in multiple types of human cancers [28–30]. To verify this, a luciferase reporter assay was carried out in HOS and U2OS cells after cotransfection with either NR2F1-AS1-wt or NR2F1-AS1-mut and either agomir-483-3p or agomir-NC.…”

Section: Resultsmentioning

confidence: 99%

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Long noncoding RNA NR2F1-AS1 enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p

Zheng

Pei

et al. 2019

Aging

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The long noncoding RNA NR2F1-AS1 has been found to promote the development of hepatocellular carcinoma and endometrial cancer. In this study, we measured NR2F1-AS1 expression in osteosarcoma (OS), determined the involvement of NR2F1-AS1 in the malignant properties of OS, and investigated the underlying mechanisms. NR2F1-AS1 was found to be upregulated in OS tumors and cell lines. The increased NR2F1-AS1 level was closely associated with advanced clinical stage and distant metastasis in patients with OS. Patients with OS in an NR2F1-AS1 high-expression group demonstrated significantly shorter overall survival than did patients in an NR2F1-AS1 low-expression group. NR2F1-AS1 knockdown inhibited OS cell proliferation, migration, and invasion and promoted cell cycle arrest and apoptosis in vitro and slowed tumor growth in vivo. NR2F1-AS1 was found to function as a competing endogenous RNA by directly sponging microRNA-483-3p (miR-483-3p) and upregulating its target oncogene forkhead box A1 (FOXA1). Finally, rescue experiments revealed that knockdown of miR-483-3p and recovery of FOXA1 expression both attenuated the influence of the NR2F1-AS1 knockdown on OS cells. Thus, NR2F1-AS1 plays an oncogenic role in OS through sponging miR-483-3p and thereby upregulating FOXA1, suggesting an additional target for osteosarcoma therapeutics.

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Section: Discussionsupporting

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Long noncoding RNA NR2F1-AS1 enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p

Zheng

Pei

et al. 2019

Aging

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“…Overexpressed miR‐483‐5p could inhibit proliferation and metastasis of renal cancer cells, and increase the expression of E‐cadherin, and reduce the expression of N‐cadherin to reverse EMT process. Niu et al certificated that miR‐483 mimic could inhibit proliferation and migration of colorectal cancer cell 38 . Menbari et al confirmed that miR‐483‐3p could suppress the proliferation and progression in breast cancer cells 39 .…”

Section: Discussionmentioning

confidence: 99%

MiR‐483‐5p downregulation contributed to cell proliferation, metastasis, and inflammation of clear cell renal cell carcinoma

Wang

Zhu

Wang

et al. 2020

The Kaohsiung J of Med Scie

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Inflammation status are especially for tumor growth, and microRNAs (miRNAs) confirmed to participate in cancer occurrence and progression. However, the role of miR‐483‐5p and the relation with inflammation have not been elucidated in renal cell cancer (RCC). In this study, we intended to explore miR‐483‐5p expression and the relationship of inflammation status in clear cell renal cell cancer (ccRCC). Using microarray and qRT‐PCR (Quantitative Real‐time Polymerase Chain Reaction), we investigated the miR‐483‐5p expression in plasma and ccRCC cancer tissues. Then, we analyzed the correlation of miR‐483‐5p with clinicopathological parameters and inflammation status in ccRCC. Receiver operator characteristic (ROC) curves analysis was used to analyze the discrimination efficiency of miR‐483‐5p. in vitro experiments explored the biological role of miR‐483‐5p in renal cancer cells. miR‐483‐5p expression was upregulated in plasma of 5 patients with microarray and 12 patients with qRT‐PCR in ccRCC at day 7 postoperatively. In addition, low expression of miR‐483‐5p was found in 58 ccRCC cancer tissues when compared with non‐cancerous tissues. miR‐483‐5p could sufficiently discriminate ccRCC with the area under the curve (AUC) of 0.739 (P < .0001) from normal tissues. Higher expression of miR‐483‐5p was positively related to lower tumor stage and higher relative expression of miR‐483‐5p was inversely related to neutrophil‐to‐lymphocyte ratio (NLR) (P = .03) and lymphocyte‐to‐monocyte ratio (LMR) (P = .026). Overexpression of miR‐483‐5p lead to reverse epithelial‐mesenchymal transition (EMT) process, restrain cell proliferation and metastasis of renal cancer cells. Our findings suggest that miR‐483‐5p expression is negatively correlation with inflammation status and may be a potential plasma biomarker for ccRCC.

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“…25 A previous study has demonstrated that miR-483 inhibited cell proliferation and migration in colon cancer. 26 Wang et al have indicated that miR-483 suppressed the proliferation of glioma cells. 27 However, the effect of miR-483 in glioma was still unknown.…”

Section: Discussionmentioning

confidence: 99%

<p>MiR-483 Targeted SOX3 to Suppress Glioma Cell Migration, Invasion and Promote Cell Apoptosis</p>

Lu¹,

Yu²,

Zhang³

et al. 2020

OTT

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Objective: Glioma is the most common malignant brain tumor that has high aggressiveness. The aim of this study was to investigate the potential therapeutic targets for gliomas. Materials and Methods: Real-time quantitative polymerase chain reaction (RT-qPCR) was employed to calculate the expression of miRNA and genes. The connection between the expression of miR-483 and patients' overall survival rate was evaluated using Kaplan-Meier analysis. In addition, the underlying mechanism was detected using luciferase assay. Results: The expression level of miR-483 was significantly decreased in glioma tissue samples and cell lines, compared to the adjacent tissues and normal cell lines. Downregulation of miR-483 or upregulation of SOX3 was associated with overall survival of glioma patients. Additionally, overexpression of miR-483 promotes cell invasion and migration and inhibits apoptosis. In addition, miR-483 directly targeted to SOX3, and the expression of miR-483 has a negative correlation with SOX3 in glioma tissues. SOX3 reversed partial functions of miR-483 on cell migration, invasion, and promoted cell apoptosis in glioma. Conclusion: MiR-483 inhibited glioma cell migration, invasion, and promoted glioma cell apoptosis by targeting SOX3. MiR-483 maybe acted as a potential target for the treatment of glioma.

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Mir‐483 inhibits colon cancer cell proliferation and migration by targeting TRAF1

Cited by 19 publications

References 27 publications

Long noncoding RNA NR2F1-AS1 enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p

Long noncoding RNA NR2F1-AS1 enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p

MiR‐483‐5p downregulation contributed to cell proliferation, metastasis, and inflammation of clear cell renal cell carcinoma

<p>MiR-483 Targeted SOX3 to Suppress Glioma Cell Migration, Invasion and Promote Cell Apoptosis</p>

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