MiRNA-based therapeutic intervention of cancer

Naidu, Srivatsava; Magee, Peter; Garofalo, Michela

doi:10.1186/s13045-015-0162-0

Cited by 117 publications

(75 citation statements)

References 113 publications

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“…m iR NAs a re deregulated in numerous human cancers (23,24). Previous studies have demonstrated that miRNAs are reliable and cost-effective biomarkers that can be utilized in the diagnosis and assessment of the progression, therapeutic response and prognosis of a wide spectrum of malignant tumors, including esophageal cancer (7,(25)(26)(27). A better understanding of the miRNAs associated with particular cancers would provide valuable insights for treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have identified an association between dysregulated miRNA expression and cancer diagnosis (28,29). In addition, it has been demonstrated that miRNAs modulate numerous signaling pathways and regulate the expression of thousands of genes (7,30). The current gold standard of cancer diagnosis is a pathological diagnosis, due to the heterogeneous nature of tumors.…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs/miRs) are small, endogenous non-coding RNAs that are highly conserved across a variety of eukaryotic species (6,7). Since the first report to highlight the roles of miRNAs in chronic lymphocytic leukemia (8), several studies have demonstrated that the deregulation of miRNA expression has a profound impact on human biological and pathological processes through a number of molecular mechanisms (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Liu¹,

Wang²,

Liu³

et al. 2017

Oncology Letters

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Liu¹,

Wang²,

Liu³

et al. 2017

Oncology Letters

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“…An increasing number of studies have suggested that miRNAs perform a crucial role in regulating cancer cells by acting as oncogenes or tumor suppressers (9)(10)(11). Therefore, miRNAs may serve as potential biomarkers and targets for the diagnosis and treatment of various types of cancer (12). miRNA-34a is an important regulator of tumor suppression, and acts by controlling cellular proliferation, cellular differentiation and the survival of cancer cells (13).…”

Section: Introductionmentioning

confidence: 99%

miRNA-34a enhances the sensitivity of gastric cancer cells to treatment with paclitaxel by targeting E2F5

Zhao

2017

Oncology Letters

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Abstract. Gastric cancer (GC) is one of the most common types of malignant cancer worldwide, however improvements are required to the current therapies for GC. Although paclitaxel is one of the most promising chemotherapeutic agents in clinical use for GC, the resistance to paclitaxel that develops during treatment is a major obstacle to further treatments of GC. The present study reports that micro (mi) RNA-34a, a tumor suppressor in various types of cancer, may be an important regulator of chemoresistance in GC, as miRNA-34a mimics and inhibitors, enhance and inhibit the chemotherapeutic efficacy of paclitaxel, respectively. In addition, the present study identified that E2F transcription factor 5 (E2F5), a key oncogenic protein, is the direct target candidate of miRNA-34a. Previous studies have demonstrated that the inhibition of E2F5 by specific E2F5 small interfering RNA also increases the sensitivity of GC cells to paclitaxel. In conclusion, the present data suggest that miRNA-34a enhances the treatment of sensitive GC cells to paclitaxel by targeting E2F5. Therefore, the miRNA-34a/E2F5 axis appears to be a potential promising therapeutic target for overcoming the chemotherapeutic resistance of GC.

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“…Several miRs have been reported to have an important role in tumor metastasis (45)(46)(47). Furthermore, since miRs regulate multiple target genes simultaneously, miR-based therapy is expected to be more efficient than the traditional single target therapy (48,49). In the present study, miR-429 was shown to be an important regulator in tumor cell migration and invasion, which emphasized an essential role of miR-429 in regulating GC metastasis.…”

Section: Discussionmentioning

confidence: 53%

MicroRNA-429 inhibits gastric cancer migration and invasion through the downregulation of specificity protein 1

Yang

Liu

et al. 2017

Oncology Letters

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Abstract. microRNAs (miRs) have been reported to have an important role in tumorigenesis and tumor progression. Although miR-429 has been shown to be downregulated in gastric cancer (GC), the function of miR-429 in the metastasis of GC has yet to be investigated. In the present study, GC cells were transfected with miR-429, and reverse transcription-quantitative polymerase chain reaction, cell migration assays, cell invasion assays, western blot analysis and luciferase assays were conducted to investigate the role of miR-429 in GC cells. It was demonstrated that miR-429 expression was markedly increased following transfection of the cells with miR-429. Furthermore, miR-429 was shown to inhibit the migration and invasion of GC cell lines. In addition, this study provided evidence that miR-429 directly targets specificity protein 1 in GC cells. The results of the present study may enhance current knowledge regarding the molecular basis of cancer metastasis and provide a potential therapeutic strategy for GC.

show abstract

MiRNA-based therapeutic intervention of cancer

Cited by 117 publications

References 113 publications

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

miRNA-34a enhances the sensitivity of gastric cancer cells to treatment with paclitaxel by targeting E2F5

MicroRNA-429 inhibits gastric cancer migration and invasion through the downregulation of specificity protein 1

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