miRNAs in head and neck cancer revisited

Nagadia, Rahul Harshad; Pandit, Pratibala; Coman, William B.; Cooper-White, Justin J.; Punyadeera, Chamindie

doi:10.1007/s13402-012-0122-4

Cited by 82 publications

(68 citation statements)

References 62 publications

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“…Recently, the use of saliva to detect different pathologies, including cancer, has been shown to hold great promise [6][7][8][9][10]. Indeed, saliva sampling is rapidly expanding and may provide a non-invasive and cheap alternative to traditional tissue and blood sampling [11].…”

Section: Introductionmentioning

confidence: 99%

A novel saliva-based microRNA biomarker panel to detect head and neck cancers

et al. 2014

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Section: Introductionmentioning

confidence: 99%

A novel saliva-based microRNA biomarker panel to detect head and neck cancers

et al. 2014

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“…They are short (18-25 nucleotide), regulatory, non-coding single strands of RNA, which have diverse roles in cellular functions, including development, differentiation, proliferation, inflammation, immune responses, stress responses, and apoptosis [20,21]. miRNAs were initially linked to human cancers because of their proximity to chromosomal breakpoints or areas of instability, and dysregulated ex- pression levels in several human cancers [19].…”

Section: Microrna Characteristics and Biogenesismentioning

confidence: 99%

An Update on Cellular MicroRNA Expression in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma

Emmett

Whiteman²,

Panizza

et al. 2018

Oncology

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Squamous cell carcinoma of mucosal sites in the head and neck (HNSCC) is the sixth most common cause of cancer worldwide, and despite advances in conventional management, it still has significant morbidity and mortality associated with both diagnosis and treatment. Advances in our understanding of the biological mechanisms underlying this disease have demonstrated a significant difference between human papillomavirus (HPV)-associated, HPV and tobacco associated, and HPV-negative disease. It remains important to further elucidate the biologic and genetic differences between HPV-associated and tobacco-associated disease, with the aim of earlier diagnosis through screening, and advances in management including the development of novel therapeutic agents. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression, and have effects on almost every cellular function, and have potentially important applications to diagnosis, management and prognosis in HNSCC. Establishing a cellular miRNA expression profile for HPV-associated disease may therefore have important implications for the screening and treatment of this disease. This review summarises the current findings regarding miRNA expression in mucosal HNSCC, and focuses particularly on miRNA expression in HPV-associated tumours.

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“…This stability is due to their inclusion in lipid or lipoprotein complexes, such as apoptotic bodies, microvesicles, or exosomes, which prevent their degradation by RNases. 126 The stability combined with the good accessibility make circulating miRNAs attractive biomarker candidates. Circulating miR-142-3p, miR-186-5p, miR-195-5p, miR-374b-5p, and miR-574-3p represent the most promising markers for prognosis and therapy monitoring in the plasma of HNSCC patients.…”

Section: Mirnas As Predictive Biomarkers In Oral Carcinomamentioning

confidence: 99%

Impact of microRNA dynamics on cancer hallmarks: An oral cancer scenario

Manasa

Kannan

2017

Tumour Biol.

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MicroRNAs are endogenous small noncoding RNAs that negatively regulate gene expression at posttranscriptional level. The discovery of microRNAs has identified a new layer of gene regulation mechanisms, which play a pivotal role in development as well as in various cellular processes, such as proliferation, differentiation, cell growth, and cell death. Deregulated microRNA expression favors acquisition of cancer hallmark traits as well as transforms the tumor microenvironment, leading to tumor development and progression. Many recent studies have revealed altered expression of microRNAs in oral carcinoma with several microRNAs shown to have key biological role in tumorigenesis functioning either as tumor suppressors or as tumor promoters. MicroRNA expression levels correlate with clinicopathological variables and have a diagnostic and prognostic value in oral carcinoma. For these reasons, microRNA has been a hot topic in oral cancer research for the last few years. In this review, we attempt to summarize the present understanding of microRNA deregulation in oral carcinoma, their role in acquiring cancer hallmarks, and their potential diagnostic and prognostic value for oral cancer management.

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miRNAs in head and neck cancer revisited

Cited by 82 publications

References 62 publications

A novel saliva-based microRNA biomarker panel to detect head and neck cancers

A novel saliva-based microRNA biomarker panel to detect head and neck cancers

An Update on Cellular MicroRNA Expression in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma

Impact of microRNA dynamics on cancer hallmarks: An oral cancer scenario

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