Mitochondria, Bioenergetics and Apoptosis in Cancer

Burke, Peter J.

doi:10.1016/j.trecan.2017.10.006

Cited by 343 publications

(250 citation statements)

References 65 publications

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“…However, when the balance of apoptosis regulation is broken, it can lead to pathological reactions. For example, excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer . We evaluated apoptosis levels of L929 cells cultured in different concentrations of FPHU material extracts for 24 and 48 h by flow cytometry.…”

Section: Resultsmentioning

confidence: 99%

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Liu

Zhang

et al. 2018

J of Applied Polymer Sci

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Polyurethane (PU) is widely used in biomedical applications owing to its excellent physical and chemical properties. As an isocyanate‐free PU material, fluorescent poly(hydroxyurethane) (FPHU) is synthesized from the addition of the cyclic carbonates with amines rather than the toxic isocyanate with diols, which reduces the possible injury to the human due to trace amounts of the isocyanate residues. Herein, we report the biocompatibility of a FPHU that can be synthesized from carbon dioxide, bisepoxides, and diamine in tandem. Of unique, FPHU exhibits a strong blue fluorescence and is selectively sensitive to Fe3+ with a detection limit of 4.56 μM. The overall results of the methylthiazolyldiphenyl‐tetrazolium, cytokine release, and hemolysis assays for FPHU indicates that FPHU has much lower cytotoxicity and immunotoxicity compared with the traditional isocyanate PU, as well as a good blood compatibility with less than 5% hemolysis rate. Therefore, FPHU presents as a kind of safer PU and can be prospectively applied in medical materials.

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Section: Resultsmentioning

confidence: 99%

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Liu

Zhang

et al. 2018

J of Applied Polymer Sci

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“…Vitamin C decreases the mitochondrial membrane potential in A375 cells. The loss of mitochondrial membrane potential is a common early event in apoptosis induced by a variety of stimuli (13,14). The integrity of the mitochondrial membrane potential was monitored during vitamin C-induced apoptosis using the mitochondrial membrane potential-sensitive dye JC-1 and flow cytometry (Fig.…”

Section: Vitamin C Induces Apoptosis In A375 Cells To Verify the Effmentioning

confidence: 99%

Vitamin�C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways

Chen

et al. 2019

Oncol Lett

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Melanoma is the most malignant type of skin cancer and is resistant to numerous chemotherapeutic and radiotherapy-based treatment approaches due to the activation of rapid and reversible pro-survival signaling pathways. As a result, patients will often present with a poor prognosis. Therefore, novel preventive methods and treatments are urgently required for patients with melanoma. Vitamin C (also known as L-ascorbic acid) is a water-soluble vitamin that is widely used as a dietary additive and has been demonstrated to exhibit anti-cancer properties. In the present study, the effects of vitamin C in human melanoma A375 cells, and the mechanisms underlying these effects were investigated. Vitamin C potently suppressed human melanoma A375 cell proliferation by inducing apoptosis in A375 cells. Induction of apoptosis was related to caspase-9 and caspase-3 activation and the mitochondrial membrane potential of A375 cells significantly decreased in the presence of vitamin C. Furthermore, vitamin C induced apoptosis in A375 cells by activating the Bax-and Bcl-2-mediated mitochondrial pathway. These results indicate that vitamin C may be a potentially useful clinical anti-tumor drug for treating patients with melanoma.Abbreviations: Bcl-2, BCL2 apoptosis regulator; Bax, BCL2 associated X; ROS, reactive oxygen species; JC-1, 5,5', 6,6'-tetrachloro-1,1',3,3'-tetraethyl enzamidazolocarbocyanin iodide

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“…Recently, new evidence points to a more intimate link between mitochondrial bioenergetics and apoptosis, mediated by the remodeling of the mitochondrial ultrastructure during apoptosis . Our previous study reported that mitochondrial bioenergetics were attenuated by short‐term inhibition of MALT1 protease in ABC‐DLBCL cells .…”

Section: Discussionmentioning

confidence: 94%

“…These findings suggested that c-Jun was a downstream target of and was managed by MALT1 protease in Recently, new evidence points to a more intimate link between mitochondrial bioenergetics and apoptosis, mediated by the remodeling of the mitochondrial ultrastructure during apoptosis. 35 Our previous study reported that mitochondrial bioenergetics were attenuated by short-term inhibition of MALT1 protease in ABC-DLBCL cells. 29 This inhibitory effect was also preserved even with prolonged MALT1 protease inhibition, revealing that irreversible destruction of mitochondrial bioenergetics is caused by MALT1 protease inhibition.…”

Section: Regulation Of Gls1 Expression By Malt1 Protease Was Dependmentioning

confidence: 95%

Antiapoptotic properties of MALT1 protease are associated with redox homeostasis in ABC‐DLBCL cells

Zhu

Tang

Lei

et al. 2019

Molecular Carcinogenesis

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Mucosa‐associated lymphoid tissue lymphoma translocation protein‐1 (MALT1) protease presents crucial antiapoptotic properties in activated B cell‐like diffuse large B‐cell lymphoma (ABC‐DLBCL); however, the mechanism is unclear. Here, we reported that inhibition of MALT1 protease in ABC‐DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced oxygen consumption rate. These alterations induced by MALT1 protease inhibition were associated with reduced expression of glutaminase (GLS1) and glutathione levels. We further show that MALT1 protease was required for the activation and nuclear translocation of c‐Jun, which functions as a transcription factor of the GLS1 gene by binding directly to its promoter region. Taken together, MALT1 protease maintained mitochondrial redox homeostasis and mitochondrial bioenergetics through the MALT1‐c‐Jun‐GLS1‐coupled metabolic pathway to defend against apoptosis in ABC‐DLBCL cells, which raises exciting possibilities regarding targeting of the MALT1‐c‐Jun‐GLS1 axis as a potential therapeutic strategy against ABC‐DLBCL.

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Mitochondria, Bioenergetics and Apoptosis in Cancer

Cited by 343 publications

References 65 publications

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Vitamin�C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways

Antiapoptotic properties of MALT1 protease are associated with redox homeostasis in ABC‐DLBCL cells

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