Mitochondrial Regulation in Pluripotent Stem Cells

Xu, Xiuling; Duan, Shunlei; Yi, Fei; Ocampo, Alejandro; Liu, Guanghui; Belmonte, Juan Carlos Izpisúa

doi:10.1016/j.cmet.2013.06.005

Cited by 350 publications

(321 citation statements)

References 68 publications

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“…Ample reports showed that the mitochondrial metabolism plays a pivotal role in stem cell proliferation and differentiation (Funes et al, 2007;Mandal et al, 2011;Xu et al, 2013). It is known that riboflavin and its cofactors are important components for mitochondrial metabolism (Hoppel and Tandler, 1975;Barile et al, 1997;Nelson and Cox, 2013).…”

Section: Discussionmentioning

confidence: 99%

Studies on organogenesis during regeneration in the earthworm, Eudrilus eugeniae, in support of symbiotic association with Bacillus endophyticus

Subramanian¹,

Sudalaimani²,

Christyraj³

et al. 2017

Turk J Biol

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Organogenesis and animal adaptation upon loss of body parts are crucial events in regeneration of all traits, and both are uncovered areas in biology. The organogenesis of the mouth and anus during regeneration was studied in Eudrilus eugeniae. It was found that the earthworm regenerates a functional mouth and anus in six days. During the course of organogenesis, the earthworm adopts unique starvation behavior for 5 days, and the starvation triggers the gut microflora of E. eugeniae to produce riboflavin. One of the efficient riboflavin-producing bacteria, Bacillus endophyticus, confirmed through 16S rRNA sequencing, has been isolated from its gut. The symbiotic association provides shelter and nutrition to the bacterium and the earthworm in return gets riboflavin to maintain homeostasis during the starvation period of early regeneration.

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Section: Discussionmentioning

confidence: 99%

Studies on organogenesis during regeneration in the earthworm, Eudrilus eugeniae, in support of symbiotic association with Bacillus endophyticus

Subramanian¹,

Sudalaimani²,

Christyraj³

et al. 2017

Turk J Biol

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“…Interestingly, while the close similarity between iPS cell generation and the acquisition of CSC is shedding new light on the roles of bona fide oncogenes, tumor suppressor genes, transcription factors and chromatin regulators, in mediating the transition from differentiated-to-stem cell states in cancer tissues, an increasing number of experimental studies have consistently revealed that, similar to embryonic and adult stem cells, iPS cells are metabolically distinct from their differentiated counterparts. [25][26][27][28][29][30][31][32] Moreover, the precise metabolic properties of stem cells appear to be functionally relevant for stem cell identity and specification regardless of their cellular sizes or cell duplication dynamics, implicating a metabolism-centric regulation of stemness and cell fate.…”

Section: Metabolic Control Of Cancer Cell Stemness: Lessons From Ips mentioning

confidence: 99%

Metabolic control of cancer cell stemness: Lessons from iPS cells

Menendez

2015

Cell Cycle

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“…Several reports demonstrated an important role for mitochondria in the differentiation of stem cells. 27 The metabolic transition from glycolysis to OXPHOS in mitochondria is necessary for cell differentiation. Mitochondria undergo significant changes to provide higher amounts of energy to sustain specialized functions in different tissues.…”

Section: Resistance To Long-term Fr In Nscsmentioning

confidence: 99%

A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells

et al. 2017

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Mitochondria play a key role in maintaining cellular homeostasis during stress responses, and mitochondrial dysfunction contributes to carcinogenesis, aging, and neurologic disease. We here investigated ionizing radiation (IR)-induced mitochondrial damage in human neural progenitor stem cells (NSCs), their differentiated counterparts and human normal fibroblasts. Long-term fractionated radiation (FR) with low doses of X-rays for 31 d enhanced mitochondrial activity as evident by elevated mitochondrial membrane potential (DCm) and mitochondrial complex IV (cytochrome c oxidase) activity to fill the energy demands for the chronic DNA damage response in differentiated cells. Subsequent reduction of the antioxidant glutathione via continuous activation of mitochondrial oxidative phosphorylation caused oxidative stress and genomic instability in differentiated cells exposed to longterm FR. In contrast, long-term FR had no effect on the mitochondrial activity in NSCs. This cell type showed efficient DNA repair, no mitochondrial damage, and resistance to long-term FR. After high doses of acute single radiation (SR) (> 5 Gy), cell cycle arrest at the G2 phase was observed in NSCs and human fibroblasts. Under this condition, increase in mitochondria mass, mitochondrial DNA, and intracellular reactive oxygen species (ROS) levels were observed in the absence of enhanced mitochondrial activity. Consequently, cellular senescence was induced by high doses of SR in differentiated cells.In conclusion, we demonstrated that mitochondrial radiation responses differ according to the extent of DNA damage, duration of radiation exposure, and cell differentiation.

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Mitochondrial Regulation in Pluripotent Stem Cells

Cited by 350 publications

References 68 publications

Studies on organogenesis during regeneration in the earthworm, Eudrilus eugeniae, in support of symbiotic association with Bacillus endophyticus

Studies on organogenesis during regeneration in the earthworm, Eudrilus eugeniae, in support of symbiotic association with Bacillus endophyticus

Metabolic control of cancer cell stemness: Lessons from iPS cells

A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells

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