Mitochondrial Respiratory Complex Biogenesis: Communication, Gene Expression and Assembly

Giegé, Philippe

doi:10.1002/9781119312994.apr0326

Cited by 3 publications

(3 citation statements)

References 166 publications

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“…Careful examination of the A. thaliana genome revealed that two genes encode similar yeast COX17 homologs, respectively, AtCOX17-1 and AtCOX17-2 which functions remain to be elucidated. However, since COX17 is a highly conserved protein, one can assume that the six conserved cysteine residues of Cox17 that participate in the ligation of Cu(I) in both yeast and mammalia perform a similar function in plants to allow Cu transfer from cytosol to the mitochondrial inter-membrane space ( Palumaa et al, 2004 ; Giegé, 2007 ).…”

Section: Copper Trafficking In Plantsmentioning

confidence: 99%

“…In particular, HCC1 loss of function was shown to disrupt COX activities whereas HCC2 may rather indirectly act in redox regulation ( Attallah et al, 2011 ; Steinebrunner et al, 2014 ). Finally, the presence of a COX11 homolog in the Arabidopsis genome, being potentially able to bind Cu(I) and to participate in the formation of the Cu B metal center of the COX, suggests a role of this later at some terminal stage of cytochrome c oxidase synthesis, notably in inserting Cu into subunit I ( Horng et al, 2004 ; Giegé, 2007 ).…”

Section: Copper Trafficking In Plantsmentioning

confidence: 99%

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Copper Trafficking in Plants and Its Implication on Cell Wall Dynamics

et al. 2016

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In plants, copper (Cu) acts as essential cofactor of numerous proteins. While the definitive number of these so-called cuproproteins is unknown, they perform central functions in plant cells. As micronutrient, a minimal amount of Cu is needed to ensure cellular functions. However, Cu excess may exert in contrast detrimental effects on plant primary production and even survival. Therefore it is essential for a plant to have a strictly controlled Cu homeostasis, an equilibrium that is both tissue and developmentally influenced. In the current review an overview is presented on the different stages of Cu transport from the soil into the plant and throughout the different plant tissues. Special emphasis is on the Cu-dependent responses mediated by the SPL7 transcription factor, and the crosstalk between this transcriptional regulation and microRNA-mediated suppression of translation of seemingly non-essential cuproproteins. Since Cu is an essential player in electron transport, we also review the recent insights into the molecular mechanisms controlling chloroplastic and mitochondrial Cu transport and homeostasis. We finally highlight the involvement of numerous Cu-proteins and Cu-dependent activities in the properties of one of the major Cu-accumulation sites in plants: the cell wall.

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Section: Copper Trafficking In Plantsmentioning

confidence: 99%

Section: Copper Trafficking In Plantsmentioning

confidence: 99%

Copper Trafficking in Plants and Its Implication on Cell Wall Dynamics

et al. 2016

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“…Both groups concluded that Viscum mitochondrial genes are very deviating from genes of even closely related taxa, and that they lack all genes of complex I (NAD-ubiquinone oxidoreductase complex). The NADH-ubiquinone oxidoreductase complex (mitochondrial complex I) is the largest in the plant mitogenome (in A. thaliana it is comprised of 48 subunits, 9 of which are encoded in its mitogenome (Giegé 2007)). It is there, where the initial electron transfer occurs that starts the oxidative phosphorylation pathway (Remacle et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Complete loss of mitochondrial complex I genes in mistletoes (Viscaceae) and evidence of polyadenylated mitochondrial transcripts shown by whole transcriptome sequencing

Zervas

Takenaka

et al. 2021

Preprint

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The profound absence of mitochondrial complex I (NADH-ubiquinone oxidoreductase) genes from the mitogenome of Viscum spp. and the rapid rates of molecular evolution characterizing most of their remaining mitochondrial genes raise questions regarding the possible transfer of the entire nad gene set to the nucleus, as well as for the functionality of the remaining highly divergent genes. Using whole transcriptome sequencing in three species of Viscaceae: V. album, V. crassulae, and Phoradendron leucarpum we were able to confirm transcription of all previously identified genes. However, we did not detect any nad gene transcripts, thus, providing further evidence of the complete loss of complex I in Viscaceae. The results from transcriptome sequencing also revealed that levels and patterns of RNA editing were not different from those found in autotrophic plant species. Hence, RNA editing is not a means of restoring conserved domains or folding sites of the proteins coded for by the divergent mitochondrial genes. Since we were able to recover mitochondrial genes transcripts following a sequencing protocol targeted towards polyadenylated mRNA molecules, it is suggested that mitochondrial genes undergo post-transcriptional polyadenylation in Viscaceae.

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Massive gene loss in mistletoe (Viscum, Viscaceae) mitochondria

Petersen

Cuenca

Møller

et al. 2015

Sci Rep

103

134

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Parasitism is a successful survival strategy across all kingdoms and has evolved repeatedly in angiosperms. Parasitic plants obtain nutrients from other plants and some are agricultural pests. Obligate parasites, which cannot complete their lifecycle without a host, may lack functional photosystems (holoparasites), or have retained photosynthesis (hemiparasites). Plastid genomes are often reduced in parasites, but complete mitochondrial genomes have not been sequenced and their mitochondrial respiratory capacities are largely unknown. The hemiparasitic European mistletoe (Viscum album), known from folklore and postulated therapeutic properties, is a pest in plantations and forestry. We compare the mitochondrial genomes of three Viscum species based on the complete mitochondrial genome of V. album, the first from a parasitic plant. We show that mitochondrial genes encoding proteins of all respiratory complexes are lacking or pseudogenized raising several questions relevant to all parasitic plants: Are any mitochondrial gene functions essential? Do any genes need to be located in the mitochondrial genome or can they all be transferred to the nucleus? Can parasitic plants survive without oxidative phosphorylation by using alternative respiratory pathways? More generally, our study is a step towards understanding how host- and self-perception, host integration and nucleic acid transfer has modified ancestral mitochondrial genomes.

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Mitochondrial Respiratory Complex Biogenesis: Communication, Gene Expression and Assembly

Abstract: The sections in this article areIntroductionBiogenesis of Prosthetic Groups Essential for RespirationMitochondrial Respiratory Complexes AssemblyGene Expression for the Biogenesis of Mitochondrial Respiratory ComplexesMitochondria–Nucleus Cross TalkConcluding RemarksAcknowledgements

Cited by 3 publications

References 166 publications

Copper Trafficking in Plants and Its Implication on Cell Wall Dynamics

Copper Trafficking in Plants and Its Implication on Cell Wall Dynamics

Complete loss of mitochondrial complex I genes in mistletoes (Viscaceae) and evidence of polyadenylated mitochondrial transcripts shown by whole transcriptome sequencing

Massive gene loss in mistletoe (Viscum, Viscaceae) mitochondria

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