Mitochondrial unfolded protein-related responses across kingdoms: similar problems, different regulators

Tran, Huy Cuong; Aken, Olivier Van

doi:10.1016/j.mito.2020.05.009

Cited by 55 publications

(37 citation statements)

References 111 publications

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“…Other indicators of premature aging include unfolded protein response (UPR) associated with mitochondria and ER (UPR MT and UPR ER , respectively) ( Lopez-Otin et al., 2013 ). Upon activation, these UPR pathways increase the expression of chaperones and heat shock proteins such as hsp-6 and hsp-60 (UPR MT ) ( Tran and Van Aken, 2020 ) and hsp-4/Bip (UPR ER ) ( Ron and Walter, 2007 ). We found that GFP fluorescence of all three markers, namely hsp-6 :: GFP, hsp-60 :: GFP , and hsp-4::GFP, was significantly increased in pry-1(RNAi) day-8 adults compared with that in controls (70%, 40%, and 50% higher, respectively, p < 0.01) ( Figures 2 C and 2D).…”

Section: Resultsmentioning

confidence: 99%

Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling

et al. 2020

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Aging is a significant risk factor for several diseases. Studies have uncovered multiple signaling pathways that modulate aging, including insulin/insulin-like growth factor-1 signaling (IIS). In Caenorhabditis elegans, the key regulator of IIS is DAF-16/FOXO. One of the kinases that affects DAF-16 function is the AMPK catalytic subunit homolog AAK-2. In this study, we report that PRY-1/Axin plays an essential role in AAK-2 and DAF-16-mediated regulation of life span. The pry-1 mutant transcriptome contains many genes associated with aging and muscle function. Consistent with this, pry-1 is strongly expressed in muscles, and muscle-specific overexpression of pry-1 extends life span, delays muscle aging, and improves mitochondrial morphology in AAK-2-DAF-16-dependent manner. Furthermore, PRY-1 is necessary for AAK-2 phosphorylation. Taken together, our data demonstrate that PRY-1 functions in muscles to promote the life span of animals. This study establishes Axin as a major regulator of muscle health and aging.

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Section: Resultsmentioning

confidence: 99%

Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling

et al. 2020

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“…In photosynthetic cells in the light, there is a massive flow of fixed carbon from the chloroplasts to the rest of the cell, especially to the mitochondria via the cytosol, but metabolic cooperation between plastids and mitochondria also takes place in darkness [ 4 , 5 ]. Retrograde signaling from the mitochondria to the nucleus probably involves export of peptides [ 6 , 7 ]. In addition to this, to grow and divide the mitochondria one needs to import the vast majority of its proteins as well as some tRNAs and rRNA [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria

et al. 2020

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To function as a metabolic hub, plant mitochondria have to exchange a wide variety of metabolic intermediates as well as inorganic ions with the cytosol. As identified by proteomic profiling or as predicted by MU-LOC, a newly developed bioinformatics tool, Arabidopsis thaliana mitochondria contain 128 or 143 different transporters, respectively. The largest group is the mitochondrial carrier family, which consists of symporters and antiporters catalyzing secondary active transport of organic acids, amino acids, and nucleotides across the inner mitochondrial membrane. An impressive 97% (58 out of 60) of all the known mitochondrial carrier family members in Arabidopsis have been experimentally identified in isolated mitochondria. In addition to many other secondary transporters, Arabidopsis mitochondria contain the ATP synthase transporters, the mitochondria protein translocase complexes (responsible for protein uptake across the outer and inner membrane), ATP-binding cassette (ABC) transporters, and a number of transporters and channels responsible for allowing water and inorganic ions to move across the inner membrane driven by their transmembrane electrochemical gradient. A few mitochondrial transporters are tissue-specific, development-specific, or stress-response specific, but this is a relatively unexplored area in proteomics that merits much more attention.

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“…Furthermore, we found that mRNA and protein levels of the mitochondrial protein import-related proteins (TOMM22 and HSPA9) were elevated in TMEM65-knock-down cells. To date, many proteins have been reported to be induced by UPR mt [ 25 , 26 ]. Some of them are mitochondrial protein import-related proteins [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Depletion of TMEM65 leads to oxidative stress, apoptosis, induction of mitochondrial unfolded protein response, and upregulation of mitochondrial protein import receptor TOMM22

Urushima

Haraguchi

Yano

2020

Biochemistry and Biophysics Reports

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Mitochondrial unfolded protein-related responses across kingdoms: similar problems, different regulators

Cited by 55 publications

References 111 publications

Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling

Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling

Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria

Depletion of TMEM65 leads to oxidative stress, apoptosis, induction of mitochondrial unfolded protein response, and upregulation of mitochondrial protein import receptor TOMM22

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