Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. ( Asteraceae ) and Veronica persica Poiret ( Plantaginaceae )

Fierăscu, Radu Claudiu; Georgiev, Milen I.; Fierăscu, Irina; Ungureanu, Camelia; Avramescu, Sorin Marius; Orţan, Alina; Georgescu, Mara; Șuțan, Anca Nicoleta; Zanfirescu, Anca; Dinu-Pîrvu, Cristina-Elena; Velescu, Bruno Ştefan; Anuța, Valentina

doi:10.1016/j.fct.2017.11.008

Cited by 53 publications

(33 citation statements)

References 53 publications

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“…Unfortunately, we could not measure the content of bioactive molecules in the A. lappa root powder samples used here. According to a previous report, A. lappa contains 19.0 µg/g d.w. of gallic acid, 4388 µg/g d.w. of chlorogenic acid, 25.6 µg/g d.w. of caffeic acid, 7.9 µg/g d.w. of p-coumaric acid, 1447 µg/g d.w. of (-)-epigallocatechin, and 496 µg/g d.w. of (-)-epicatechin [46]. The crude extracts used in the previous report were obtained from ground hade-dried plant material (20 g) in 1:1 ratio of water-ethanol (100:100 mL) at 80 • C for 2 h. Therefore, similar contents of bioactive molecules are expected in the current samples.…”

Section: Discussionmentioning

confidence: 84%

Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice

et al. 2020

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Water-soluble dietary fiber such as inulin improves the beta diversity of the intestinal microbiota of mice fed with a high-fat diet (HFD). The circadian clock is the system that regulates the internal daily rhythm, and it affects the pattern of beta diversity in mouse intestinal microbiota. Burdock (Arctium lappa) root contains a high concentration of inulin/fructan (approximately 50%) and is a very popular vegetable in Japan. Arctium lappa also contains functional substances that may affect intestinal microbiota, such as polyphenols. We compared the effects of inulin and A. lappa powder on the diversity of the intestinal microbiota of HFD-fed mice. 16S rDNA from the intestinal microbiota obtained from feces was analyzed by 16S Metagenomic Sequencing Library Preparation. It was found to have a stronger effect on microbiota than inulin alone, suggesting that inulin has an additive and/or synergic action with other molecules in A. lappa root. We examined the effects of intake timing (breakfast or dinner) of A. lappa on intestinal microbiota. The intake of A. lappa root in the evening had a stronger effect on microbiota diversity in comparison to morning intake. Therefore, it is suggested that habitual consumption of A. lappa root in the evening may aid the maintenance of healthy intestinal microbiota.

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Section: Discussionmentioning

confidence: 84%

Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice

et al. 2020

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“…(1:1, v/v) extract antioxidant activity assessed by DPPH and phosphomolybdate method was 76.23 ± 0.29% and, respectively, 269.5 mg/g ascorbic acid equivalent (Fierascu et al, 2018).…”

Section: In Vivo Studiesmentioning

confidence: 94%

“…Similar results were found in other studies in which root hydro‐EtOH extractions were performed, although in different proportions. In particular, the water/EtOH (1:1, v/v) extract antioxidant activity assessed by DPPH and phosphomolybdate method was 76.23 ± 0.29% and, respectively, 269.5 mg/g ascorbic acid equivalent (Fierascu et al, ).…”

Section: The Role Of a Lappa In Contrasting The Oxidative Stressmentioning

confidence: 99%

Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal‐based studies

Annunziata

Barrea²,

Ciampaglia

et al. 2019

Phytotherapy Research

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Diabetes is a metabolic disease highly widespread worldwide, and the most common form is the type 2 diabetes mellitus (T2DM). A large number of synthetic drugs are currently available for the treatment of diabetes; however, they present various side effects and, for this reason, people are increasingly inclined to search natural alternative treatments. Among these, Arctium lappa (A. lappa) has interesting anti‐diabetic activities, exerted by improving glucose homeostasis and reducing insulin‐resistance. In addition, A. lappa exerts a marked antioxidant activity, an effect known to play a pivotal role in the treatment of T2DM. The purpose of this review is to analyse scientific evidence in order to evaluate the role of A. lappa and its bioactive compounds in management of T2DM. The literature search performed provided only in vitro and animal‐based studies. No clinical studies have been conducted in order to investigate the effect of A. lappa on T2DM patients. However, available literature provides evidence for further clinical trials in order to confirm these claimed activities on humans.

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“…Moreover, Burdock has been used in traditional Chinese medicine and in alternative ther-apies in Europe, Asia, and North and South America [1,2]. Several parts of this medicinal herb, including, roots, leaves, seeds, and fruits, have different scientifically proven biological activities such as hypolipidemic [4], anti-inflammatory [5,6], antifungal [6], and antitumor properties [7]. In addition, Holetz et al demonstrated that the extracts of A. lappa from plants collected in southern Brazil presented bactericidal activity against Gram-positive and Gramnegative bacteria [2].…”

Section: Introductionmentioning

confidence: 99%

Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System

Fontana

Bavia

Bovo

et al. 2019

PMIO

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Arctium lappa is a perennial species of the Asteraceae family originally from Europe and Asia. Considered a weed species in the southern region of Brazil, it is popularly used as a natural anti-inflammatory. The complement system is an important component of the innate immune response. However, its exacerbated activation can lead to harmful conditions like autoimmune and inflammatory disorders. Plants that inhibit the activation of complement can be a promising tool in the treatment of inflammatory diseases. Here, we evaluated the effect of A. lappa leaves extracts on the activation of the classical and alternative pathways of complement system. Two extracts were obtained under supercritical conditions using scCO2 with ethanol as cosolvent, at 313.15K, 15 MPa (E1) and 25 MPa (E2). Classical and alternative activation were evaluated using complement fixation test. Different concentrations of A. lappa extracts E1 and E2 showed an inhibitory effect on both complement pathways, and heparin was used as control. The IC50 of E1, E2, and heparin were 28.26, 20.12 and 92.54 µg/mL for classical and 26.12, 27.70, 27.78 µg/mL for the alternative pathway. Results demonstrate that A. lappa is a promising complementary treatment for diseases associated with complement activation.

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Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. ( Asteraceae ) and Veronica persica Poiret ( Plantaginaceae )

Cited by 53 publications

References 53 publications

Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice

Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice

Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal‐based studies

Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System

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