Mitotic and Wound-Healing Activities of the Corneal Epithelium

Friedenwald, Jonas S.; Buschke, Wilhelm

doi:10.1001/archopht.1944.00890110078011

Cited by 79 publications

(35 citation statements)

References 4 publications

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“…Damage to the corneal epithelium can be repaired by the proliferation [13] and migration [14] of cells in the basal layer. A study of a mechanically induced corneal epithelial disorder in rabbit eyes of diameter 6 mm, reported that this disorder was repaired within 48 h [15].…”

Section: Comparison Between Our Methodology and That Of Previous Studiesmentioning

confidence: 99%

Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves

Kojima

Suzuki

Sasaki

et al. 2018

J Infrared Milli Terahz Waves

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The objective of this study was to develop a model of ocular damage induced by 40, 75, and 95 GHz continuous millimeter waves (MMW), thereby allowing assessment of the clinical course of ocular damage resulting from exposure to thermal damage-inducing MMW. This study also examined the dependence of ocular damage on incident power density. Pigmented rabbit eyes were exposed to 40, 75, and 95 GHz MMW from a spot-focus-type lens antenna. Slight ocular damage was observed 10 min after MMW exposure, including reduced cornea thickness and reduced transparency. Diffuse fluorescein staining around the pupillary area indicated corneal epithelial injury. Slit-lamp examination 1 day after MMW exposure revealed a round area of opacity, accompanied by fluorescence staining, in the central pupillary zone. Corneal edema, indicative of corneal stromal damage, peaked 1 day after MMW exposure, with thickness gradually subsiding to normal. Three days after exposure, ocular conditions had almost normalized, though corneal thickness was slightly greater than that before exposure. The 50% probability of ocular damage (DD 50 ) was in the order 40 > 95 ≈ 75 GHz at the same incident power densities. J Infrared Milli Terahz Waves (2018) 39:912-925 https://doi

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Section: Comparison Between Our Methodology and That Of Previous Studiesmentioning

confidence: 99%

Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves

Kojima

Suzuki

Sasaki

et al. 2018

J Infrared Milli Terahz Waves

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show abstract

“…16 Further observations and experimental studies showed that in the absence of vascular ingrowth conjunctival epi thelium on the corneal surface loses its conjunctival phe notype and becomes cornea-like. [16][17][18] This transformation of conjunctival epithelium to a corneal epithelium was described by the term 'conjunctival transdifferentiation'. This phenomenon was investigated in numerous animal studieslY-22 and led to the assumption that normal corneal epithelium is maintained by the surrounding conjunctival epithelium.…”

Section: Conjunctival Transdifferentiationmentioning

confidence: 99%

Stem cells and corneal epithelial regeneration

Kruse

1994

Eye

144

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“…4D). Although complete re-epithelialization and re-establishment of normal CE architecture requires proliferation, the initial phase of wound closure is independent of cell division (Friedenwald and Buschke, 1944;Kuwabara et al, 1976;Zagon et al, 1999). During the initial phase of cornea re-epithelialization upon a central mechanical wound, cell proliferation rates drastically decrease in cells proximal to the wound borders.…”

Section: Primary Cilia Are Not Required For Ce Wound Closurementioning

confidence: 99%

Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway

Grisanti¹,

Revenkova²,

Gordon³

et al. 2016

Journal of Cell Science

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Primary cilia have been linked to signaling pathways involved in cell proliferation, cell motility and cell polarity. Defects in ciliary function result in developmental abnormalities and multiple ciliopathies. Patients affected by severe ciliopathies, such as Meckel syndrome, present several ocular surface disease conditions of unclear pathogenesis. Here, we show that primary cilia are predominantly present on basal cells of the mouse corneal epithelium (CE) throughout development and in the adult. Conditional ablation of cilia in the CE leads to an increase in proliferation and vertical migration of basal corneal epithelial cells (CECs). A consequent increase in cell density of suprabasal layers results in a thicker than normal CE. Surprisingly, in cilia-deficient CE, cilia-mediated signaling pathways, including Hh and Wnt pathways, were not affected but the intensity of Notch signaling was severely diminished. Although Notch1 and Notch2 receptors were expressed normally, nuclear Notch1 intracellular domain (N1ICD) expression was severely reduced. Postnatal development analysis revealed that in ciliadeficient CECs downregulation of the Notch pathway precedes cell proliferation defects. Thus, we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by balancing proliferation and vertical migration of basal CECs through modulation of Notch signaling.

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Mitotic and Wound-Healing Activities of the Corneal Epithelium

Cited by 79 publications

References 4 publications

Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves

Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves

Stem cells and corneal epithelial regeneration

Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway

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