This article is about the study of homogeneous and heterogeneous reactions in the mixed convection flow of hybrid nanofluid over a moving vertical slender cylinder. It is based on the considerations of unequal diffusivity of chemical species and the numerical solutions from the nonsimilar approach. This study has found applications in many chemically reacting processes, including the processes in the biochemical systems, combustion, and catalysis. Numerically approximate solutions to a set of equations, which govern the flow, temperature, and concentrations of the chemical species with prescribed boundary constraints, are obtained by utilizing the implicit finite-difference scheme aided by the quasi-linearization technique. The impacts of several relevant parameters on various profiles and gradients are discussed with the aid of graphs and tables. From the results, the skin friction coefficient and rate of heat transport are pronounced to be more for hybrid nanofluid than nanofluid.The strength of homogeneous reaction on species concentration is found to be fewer than the heterogeneous reaction. The streamwise coordinate (nonsimilar variable) is more favorable to the concentration of autocatalyst than to the reactant concentration.