Mixed Function Oxidation and Intermediary Metabolism: Metabolic Interdependencies in the Liver

Thurman, Ronald G.; Marazzo, Donald P.; Scholz, Roland

doi:10.1007/978-1-4615-9026-2_25

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Cdna Microarrays and Discovery In Toxicology1

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2001

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Cited by 12 publications

(1 citation statement)

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“…Genes in node II, which were upregulated by peroxisome proliferators but suppressed by phenobarbital, have reported involvement in mitochondrial ␤-oxidation. This corroborates previously published findings demonstrating the induction of ␤-oxidation by peroxisome proliferators [43]. Node I contains genes that are mostly involved in the detoxification and metabolism of phenobarbital.…”

Section: Cdna Microarrays and Discovery In Toxicologysupporting

confidence: 92%

Discovery in toxicology: Mediation by gene expression array technology

Hamadeh

Bushel

Paules

et al. 2001

J Biochem & Molecular Tox

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Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and risk assessment processes will advance from the use of genomics techniques, which will lead to greater understanding of mechanism(s) of action of toxicants, development of novel biomarkers of exposure and effect, and better identification of sensitive subpopulations.

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Section: Cdna Microarrays and Discovery In Toxicologysupporting

confidence: 92%