Mixed vegetables and fruits ferment modulate the immune system in OVA‐induced mice

Abstract

Mix Vegetables and fruits fermented drinks (Fu Gui, FG‐enzyme) have long been used as food substance in Asia. FG‐enzyme is rich with vitamins, minerals, varieties of monosaccharides and antioxidants. This study investigated FG‐enzyme effect on immune modulation in OVA‐induced BALB/c mice. Thirty mice were divided into three groups, including control, single dose and triple dose groups. The immune modulation effects of FG‐enzyme were determined by assaying the cytokine secretion, splenocytes subsets populations, natural killer cell (NK cell) activity and phagocytosis. Results showed that FG‐enzyme elevate the T cell proliferation with single and triple doses in the cultured splenocytes of OVA‐induced mice compared to control. Determined phagocytosis capacity in the blood, and NK cell activity in splenocytes were found to increase only with single dose. In addition, we found increased the cytokines such as interleukin‐2, (IL‐2) and IL‐4 concentrations with single and triple doses in both ConA and OVA‐induced mice, while IL‐5 was increased only in ConA mice. Nevertheless, IL‐10 and interferon‐£^ (IFN‐£^) concentrations were increased in both ConA and OVA‐mice with triple dose only. Results from our study conclude that FG‐enzyme is able to modulate the immune system in OVA‐induced mice with subsequent maintenance of inflammatory cytokines and phagocytosis.