Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases

Kärrholm, Johan; Hourigan, Patrick; Timperley, Jonathan; Razaznejad, Reza

doi:10.1080/17453670610045687

Cited by 47 publications

(28 citation statements)

References 29 publications

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“…Recently, Kärrholm et al (2006) showed that mixing of OP-1 with morselized allograft did not improve early fixation of either the acetabular or femoral component in revision surgery of the hip. In contrast, the influence of OP-1 on impacted allograft implants was recently investigated experimentally in loaded, primary, and impaired revision settings (Soballe et al 2004).…”

Section: Discussionmentioning

confidence: 99%

No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks

2007

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Section: Discussionmentioning

confidence: 99%

No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks

2007

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“…Recombinant human BMP-2 and BMP-7 are FDA approved for augmenting spine fusion and healing of tibia shaft fractures (24;29), but use of BMPs with allograft bone have given adverse results (53). The ability of BMP-2 to induce osteoclastic differentiation and bone resorption has been shown in vitro (34;38).…”

Section: Bone Growth Factorsmentioning

confidence: 98%

Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs

Baas

2008

Acta Orthopaedica

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“…17 In a human series, radical resorption and implant loosening were found in 4 out of 10 acetabular components using BMP-7 in morselized and impacted allograft for hip revisions. 18 The combination of BMP-7 and another bisphosphonate, clodronate, given locally, was investigated in the chamber model using impacted grafts as in hip revisions. Clodronate decreased the ingrowth distance into the impacted grafts, which could be compensated by BMP-7.…”

Section: Manipulating Responses In Bone Graft Remodelingmentioning

confidence: 99%

Manipulating the anabolic and catabolic response in bone graft remodeling: Synergism by a combination of local BMP‐7 and a single systemic dosis of zoledronate

Harding

Aspenberg

Kataoka

et al. 2008

Journal Orthopaedic Research

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Remodeling of a bone graft can be influenced both by anabolic substances, such as a bone morphogenic protein (BMP) and by anticatabolic substances, such as the bisphosphonates. BMPs are potent bone anabolic substances, but also boost catabolism and cause resorption. Bisphosphonates inhibit osteoclast function and can be used to postpone resorption. In the present study a combination of both drugs was explored in a rat bone chamber model. Cancellous bone grafts were treated with either BMP-7 or saline and placed in a bone chamber implanted in the proximal tibia. After 2 weeks, an injection of either zoledronate 0.1 mg/kg or saline was given subcutaneously. The rats were killed after 6 weeks, and bone ingrowth distance into the graft and graft resorption were measured by histomorphometry. BMP-7 significantly (p ¼ 0.007) increased new bone ingrowth distance into the graft from 2.0 mm (SD ¼ 0.98 mm) in the controls to 3.1 mm (SD ¼ 0.93 mm). If bisphosphonate was not given, most of the newly formed and old graft bone was resorbed. A single injection of zoledronate significantly (p < 0.001) increased the trabecular volume/total volume to 40% (SD ¼ 9%) compared to 14% (SD ¼ 10%) in the nonbisphosphonate treated. In total, the net amount of bone increased by 400% when BMP-7 and zoledronate combined was compared to saline. A bone graft can be treated with BMP-7 to increase new bone formation and at the same time be protected against premature catabolism by a single dose of a bisphosphonate. This combination might be useful in various conditions in orthopedic reconstruction. Healing and normal physiological skeletal repair involve a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone at the disease or injury site. These pathways are mediated by a number of effector cells, primarily the catabolic bone-resorbing osteoclasts and the anabolic bone-forming osteoblasts, which produce new bone tissue to restore skeletal integrity. A balance between them is required for normal fracture repair and bone graft remodeling. Delayed healing or non-union can be a failure of the anabolic response, an increased or premature catabolic response, or sometimes both. 1 The anabolic and catabolic responses can be manipulated with pharmaceuticals, and in the bone conduction chamber, 2 we can study how drugs, separately or in combinations, influence bone formation and resorption.Bisphosphonates reduce osteoclastic catabolic activity in experimental studies. Circulating bisphosphonates bind to bone mineral, and, when the bone is resorbed by osteoclasts, bisphosphonates are internalized and interfere with cell metabolism leading to osteoclast apoptosis. 3 Systemic bisphosphonate treatment can postpone resorption of a bone graft. 4 In fractures, postponing the catabolic response and in consequence the resorption of the new-forming callus, leads to a stronger callus. 5 Bone morphogenic proteins (BMPs) bind to specific cell receptors, starting a signaling cascade that l...

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Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases

Cited by 47 publications

References 29 publications

No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks

No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks

Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs

Manipulating the anabolic and catabolic response in bone graft remodeling: Synergism by a combination of local BMP‐7 and a single systemic dosis of zoledronate

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