2013
DOI: 10.20473/ijtid.v4i4.235
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MMUNOHISTOCHEMICAL ANALYSIS OF NF-kB (P0/P) IN PATIENT WITH AGGRESSIVE AND CHRONIC PERIODONTITIS

Abstract: Background: Nuclear factor-kappaB (NF-κB) is a protein complex that plays a role in transcription factors and in response to inflammation. Periodontitis is a periodontal disorder caused by various bacteria such as A. actinomycetemcomitan and P.gingivalis whose LPS is closely related to 000). It shows that if the protein expression of NF-κB (p50) of the respondents is incremented by 1 (one) unit, the risk of chronic periodontitis increases 1.64 times. Box plot diagram shows that the distribution of the protein… Show more

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Cited by 3 publications
(5 citation statements)
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References 10 publications
(15 reference statements)
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“…IL-6 type cytokine families are cytokines consisting of IL-6, IL-11, leukaemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin-1, and neutrophil-1 / B cell stimulatory factors 3. These agents use the same receptor subunit, gp130, as a signal [19].…”
Section: Discussionmentioning
confidence: 99%
“…IL-6 type cytokine families are cytokines consisting of IL-6, IL-11, leukaemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin-1, and neutrophil-1 / B cell stimulatory factors 3. These agents use the same receptor subunit, gp130, as a signal [19].…”
Section: Discussionmentioning
confidence: 99%
“…Nuclear Factor-κB is a transcription factor and essential for the detection of activation of the innate immune response because their activation is associated with the TLR2/TLR4 receptors in the innate immune system [13]. In periodontitis bacteria that play a role are the P. gingivalis and A. actinomycetemcomitan in which LPS activates germ cells using the TLR2 pathway and/or TLR4 [5,11]. The interaction between LPS/TLR will activate NF-κB which plays a role in activating inflammatory mediators' transcription [13,32,35].…”
Section: Figure 3 Bar Chart Of Nfkb Expression Between Groupsmentioning
confidence: 99%
“…NF-κB resides in the cytoplasm in an inactive form along with a regulatory protein I-κB. The interaction between LPS/TLR activates the transcription NF-κB which plays a role in activating the transcription of inflammatory mediators [3,9,11]. NF-κB is activated by LPS in THP-1 cells, the transcription factor NF-kB is associated with metabolic and inflammatory responses, including nuclear receptors, activators of protein (AP-1), and early growth response (EGR).…”
Section: Introductionmentioning
confidence: 99%
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“…When periodontopathogenic infections 7 occur, these bacteria activate the NF-κB transcription factor through Toll Like Receptor (TLR) stimulation, which is expressed in nonspecific immune cells, including macrophage cells, dendritic, and mucosal epithelium. 5 Bitter gourd plant (Momordica charantia) is beneficial to the health of the human body. It (Momordica charantia) can be used as traditional medicine in the treatment of several diseases, as well as in inflammatory conditions.…”
Section: Introductionmentioning
confidence: 99%