The focus of the research is to explain the types and diversity of creative industry businesses, the creative economy, interacting with each other in forming their business networks, creating business agglomeration. The research method is the panel data method with five destination regions during the 2015-2017. The estimation method uses Pooled least square (PLS) and fixed effect method (FEM). The results showed that the most dominant form of creative industry business in West Sumatra was the super creative business group, accounted for 74% of the total creative industry workforce. There is. Creative professional groups more or less reach 26%. The largest is spread in the city of Padang and Bukittinggi. Changes in the concentration of industrial clusters have a positive impact on regional innovation and economic growth, an increase in the intensity of the use of R&D has a positive impact on regions with concentrations of industrial clusters, a negative impact on regions that do not yet have a creative industry cluster. The more agglomeration of industrial business is created due to the creative industry business cluster. Conversely, if industrial clusters are not yet formed, it will have a negative impact on regional innovation and regional economic growth.