The dynamic model of the front double wishbone suspension and the rear multi-link suspension of the vehicle are established. On the basis of detailed analysis of suspension kinematics, calculation method of wheel alignment angle and force calculation of suspension bushing, the influence mechanism of suspension bushing on the vehicle transient state is clarified, and the vehicle transient characteristic index is derived from the vehicle three-free dynamic model. The sensitivity analysis of the suspension bushing is carried out, and the bushing stiffness which has a great influence on the transient state of the vehicle is obtained. The bushing stiffness scale factor is used as the optimization variable, the vehicle transient characteristic index is used as the optimization target, and the NSGA-II optimization algorithm is used for multi-objective optimization. After optimization, one Pareto solution is selected to compare with the original vehicle, the comparison results show that the yaw rate gain, resonance frequency and delay time of yaw rate in the vehicle transient characteristic index are all improved, other optimization targets change less. In the steady-state comparison, the understeer tendency of the vehicle increases, and the roll angle of the vehicle increases but is within an acceptable range.