This work presents a numerical approach to compute optimal operating conditions that maximize the absorption flux into a heat exchanger designed for absorption refrigeration systems. Experimental data were obtained from a test circuit that operates in bubble absorption mode with an inner vapor distributor into a Plate Heat Exchanger-type (PHE-type) and interacts with ammonia vapor, NH3-H2O refrigerant, and cooling water. An artificial neural network (ANN) was trained to correlate the thermal properties of the solution and absorption flux in function of easily measurable parameters (concentrations, mass flows, and pressures of saturated and diluted solutions, flow and temperature of the ammonium vapor, environment temperature, and solution temperature). According to results, ANN is adequate to correlate the operational parameters and the transport phenomena inside the heat exchanger with a precision > 99%. ANN also quantitatively identified the ammonium vapor flow (43.1%), dilute solution flow (18.1%), and dilute solution concentration (13.1%) as the variables most importantly in influencing absorption flux optimization. Subsequently, a multivariable inverse artificial neural network was applied to improve the mass transfer into the PHE-type.It was identified that simultaneous optimization of the ammonia and dilute concentration flow rates improves the absorption flow performance by up to 96.3% under a worst-case scenario (ammonia flow rate<1.4 kg/min) and even 7.04% when even when operating near the amino vapor flow limit (ammonia flow rate>2.0 kg/min). Finally, it was confirmed that incorporating the diluted solution concentration into the optimization contributes to improving the performance of the absorption process 1%. Results obtained are relevant in the search to produce more competitive absorption cooling systems, demonstrating the feasibility of improving the performance of heat exchangers without structural modifications. The proposed methodology represents an interesting option to be implemented to improve performance in solar cooling systems.