Modeling of tissue heating under tunable near IR radiation

Bixler, Joel N.; Hokr, Brett H.; Oian, Chad A.; Hoffman, Aaron F.; Yakovlev, Vladislav V.; Thomas, Robert J.

doi:10.1117/12.2079979

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In future studies, either a longer incident excitation wavelength, i.e. 780 nm, will be used to reduce the acquisition time, because the skin's absorption and heating generally declines within the 400-1064 nm range as wavelength increases [48,49], or nonlinear Brillouin microscopy measurements [50,51] will be adapted for those tissue measurements.…”

Section: Resultsmentioning

confidence: 99%

Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy

Troyanova‐Wood

Meng

Yakovlev

2019

Biomed. Opt. Express

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The main objective of the present study is to evaluate the use of Brillouin microspectroscopy for differentiation of melanoma and normal tissues based on elasticity measurements. Previous studies of malignant melanoma show that the lesion is stiffer than the surrounding healthy tissue. We hypothesize that elasticity-specific Brillouin spectroscopy can be used to distinguish between healthy and cancerous regions of an excised melanoma from a Sinclair miniature swine. Brillouin measurements of non-regressing and regressing melanomas and the surrounding healthy tissues were performed. Based on the Brillouin measurements, the melanomas and healthy tissues can be successfully differentiated. The stiffness of both tumors is found to be significantly greater than the healthy tissues. Notably, we found that the elasticity of regressing melanoma is closer to that of the normal tissue. The results indicate that Brillouin spectroscopy can be utilized as a tool for elasticity-based differentiation between malignant melanoma and surrounding healthy tissue, with potential use for melanoma boundary identification, monitoring tumor progression, or response to treatment.

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Section: Resultsmentioning

confidence: 99%

Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy

Troyanova‐Wood

Meng

Yakovlev

2019

Biomed. Opt. Express

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“…[44] By maintaining the peak power of laser beams below the safety limits, [45,46] such as in the present study, in vivo measurements become feasible, providing an opportunity to implement our experimental approach in future clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Optical assessment of changes in mechanical and chemical properties of adipose tissue in diet‐induced obese rats

Troyanova‐Wood

Gobbell

Meng

et al. 2017

Journal of Biophotonics

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Obesity is becoming a leading cause of health problems world-wide. Obesity and overweight are associated with the structural and chemical changes in tissues; however, few methods exist that allow for concurrent measurement of these changes. Using Brillouin and Raman microspectroscopy, both the mechanical and chemical differences can be assessed simultaneously. We hypothesized that Brillouin spectroscopy can measure the adipose tissues’ stiffness, which increases in obesity. Samples of brown and white adipose tissues obtained from control and diet-induced obese adult rats were analyzed. The results show that both adipose tissues of the obese group exhibit a greater high-frequency longitudinal elastic modulus than the control samples, and that the brown fat is generally stiffer than white adipose. The Raman spectra indicates that the lipids’ accumulation in adipose tissue outpaces the fibrosis, and that the high-fat diet has a greater effect on the brown adipose than the white fat. Overall, the powerful combination of Brillouin and Raman microspectroscopies successfully assessed both the mechanical properties and chemical composition of adipose tissue simultaneously for the first time. The results indicate that the adipose tissue experiences an obesity-induced increase in stiffness and lipid content, with the brown adipose tissue undergoing a more pronounced change compared to white adipose.

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Modeling of tissue heating under tunable near IR radiation

Abstract: The time-temperature effects of laser radiation exposure are investigated as a function of wavelength. We experimentally measure the thermal reponse of tissue to laser radiation ranging in wavelength from 1100 nm to 1550 nm. Simulations were then performed to estimate damage thresholds.

Cited by 2 publications

References 11 publications

Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy

Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy

Optical assessment of changes in mechanical and chemical properties of adipose tissue in diet‐induced obese rats

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