The time-temperature effects of laser radiation exposure are investigated as a function of wavelength. We experimentally measure the thermal reponse of tissue to laser radiation ranging in wavelength from 1100 nm to 1550 nm. Simulations were then performed to estimate damage thresholds.

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Skin injury response to near-infrared (NIR) laser radiation between the minimum visible lesion threshold and ablation onset is not well understood. This study utilizes a 1070-nm diode-pumped Yb-fiber laser to explore the response of excised porcine skin to high-energy exposures in the suprathreshold injury region without inducing ablation. Concurrent high-speed videography is employed to determine a dichotomous response for three progressive damage categories: observable surface distortion, surface bubble formation due to contained intracutaneous water vaporization, and surface bubble rupture during exposure. Median effective dose (ED 50 ) values are calculated in these categories for 3-and 100-ms pulses with beam diameters (1∕e 2 ) of 3 mm (28, 35, and 49 J∕cm 2 ) and 7 mm (96, 141, and 212 J∕cm 2 ), respectively. Double-pulse cases are secondarily investigated. Experimental data are compared with the maximum permissible exposure limits and ablation onset simulated by a one-dimensional multiphysics model. Logistic regression analysis predicted injury events with ∼90% of accuracy. The distinction of skin response into progressive damage categories expands the current understanding of high-energy laser safety while underlining the unique biophysical effects during induced water phase change in tissue. These results prove to be useful in the diagnosis and treatment of NIR laser injuries.