Modeling of ultrasound contrast agents bubble dynamics with modified surface tension coefficient

Zheng, LuJie; Tu, Juan; Chen, Weizhong

doi:10.1007/s11434-009-0431-9

Cited by 2 publications

(4 citation statements)

References 20 publications

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“…The high compressibility and low density of the microbubbles made them highly echogenic (Riess 2003, Al-Sahhaf et al 2002, Phillips et al 1998. However, the early agents were lost within a short period of time because they quickly dissolved into the blood under high ultrasound and arterial pressures (Hoff et al 2000, Zheng et al 2009.…”

Section: Introductionmentioning

confidence: 99%

“…The second generation of UCAs were produced in an attempt to increase the lifespan of the agents in vivo whilst not sacrificing the high echogenicity (Hoff et al 2000, Zheng et al 2009, Ye 1996, Allen et al 2001, which is characteristic of the microbubble contrast agents. A range of commercially available agents were produced that consisted of a microbubble protected by a thin layer of albumin or lipid.…”

Section: Introductionmentioning

confidence: 99%

“…This is because significant increases in the echo amplitude may be achieved by accurate manufacture of the bubbles to the resonant size. A common approach to modelling the resonant microbubble is the Rayleigh-Plesset equation, and modifications thereof, which describe the oscillations in the bubble radius or volume (Zheng et al 2009, Frinking and De Jong 1997, Leighton 2007. This approach is specific to gas-filled agents.…”

Section: Introductionmentioning

confidence: 99%

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Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles

et al. 2010

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We present a novel modified theory based upon Rayleigh scattering of ultrasound from composite nanoparticles with a liquid core and solid shell. We derive closed form solutions to the scattering cross-section and have applied this model to an ultrasound contrast agent consisting of a liquid-filled core (perfluorooctyl bromide, PFOB) encapsulated by a polymer shell (poly-caprolactone, PCL). Sensitivity analysis was performed to predict the dependence of the scattering cross-section upon material and dimensional parameters. A rapid increase in the scattering cross-section was achieved by increasing the compressibility of the core, validating the incorporation of high compressibility PFOB; the compressibility of the shell had little impact on the overall scattering cross-section although a more compressible shell is desirable. Changes in the density of the shell and the core result in predicted local minima in the scattering cross-section, approximately corresponding to the PFOB-PCL contrast agent considered; hence, incorporation of a lower shell density could potentially significantly improve the scattering cross-section. A 50% reduction in shell thickness relative to external radius increased the predicted scattering cross-section by 50%. Although it has often been considered that the shell has a negative effect on the echogeneity due to its low compressibility, we have shown that it can potentially play an important role in the echogeneity of the contrast agent. The challenge for the future is to identify suitable shell and core materials that meet the predicted characteristics in order to achieve optimal echogenity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles

et al. 2010

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“…In the present study, the surface tension coefficient is assumed to be constant. However, the surface tension coefficient is varied with bubble radius with lower and upper limits [15], which is needed to be considered in future work.…”

Section: The Effect Of Ultrasound Pnp Valuesmentioning

confidence: 99%

Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

Shen¹,

Wang²,

Chin³

et al. 2012

Chin. Sci. Bull.

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The interaction between microbubble and elastic microvessel wall has been hypothesized to be important in the mechanisms of therapeutic ultrasound applications. In this study, a 2D axisymmetric finite element numerical model is established to study the interaction between elastic microvessel wall and oscillating microbubble in low frequency ultrasound field using fluid solid interaction method. The numerical results show that the bubble oscillation induces the vessel wall dilation and depression. The von Mises stress distribution over the microvessel wall is heterogeneous and the maximum value of the midpoint on the inner vessel wall could reach 0.23 MPa and 1.32 MPa under PNP 0.2 MPa and 0.5 MPa, respectively. When the bubble collapses, the circumferential stress decreases rapidly and the transmural pressure increases dramatically. Noticeably, the circumferential stress becomes compressive with the maximum magnitude 1.83 MPa under PNP 0.5 MPa, larger than the maximum tension value. It is possible that the rapid compression stress during bubble collapse plays important role in mechanical effect on microvessel wall endothelial lining disruption. microbubble, elastic microvessel, finite element method, ultrasound Citation:Shen Y Y, Wang T F, Chin C T, et al. Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method.

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Modeling of ultrasound contrast agents bubble dynamics with modified surface tension coefficient

Cited by 2 publications

References 20 publications

Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles

Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles

Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

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