Modelling of membrane cascades for the purification of oligosaccharides

Montesdeoca, Víctor Aguirre; Padt, A. van der; Boom, R.M.; Janssen, A.E.M.

doi:10.1016/j.memsci.2016.08.031

Cited by 26 publications

(37 citation statements)

References 27 publications

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“…5A shows that the concentration of monosaccharides (mainly galactose) decreased rapidly during CVD with time extension and V c /V f increase. Notably, the decrease rate ranked from high to low was monosaccharides > disaccharides (lactose > lactulose), thus leading to a slow decrease in Y Lu but a progressive increase in Pu Lu according to Eqns (15) and (16). During the CVD process, no irreversible fouling occurred, with J v increasing slightly from 56.9 to 58.7 L m −2 h −1 (Fig.…”

Section: Cvd and Vvd Modes For Purification Of Lactulose Syrupmentioning

confidence: 94%

“…Several parameters may have a pronounced influence on the diafiltration mode process, such as rejection coefficient, permeation factor, volume dilution ratio and volume concentration ratio . Nevertheless, modeling plays an important role in how to use the proper parameters with clear physical meaning to describe and clarify the whole diafiltration process …”

Section: Introductionmentioning

confidence: 99%

“…10,14 NF membranes with low molecular weight cut-off (MWCO 100-1000 Da) are especially appropriate for the desalination and separation of small molecular solutes from syrup mixtures. 15 Much interest has been focused on the operational modes of NF, [16][17][18] including constant volume diafiltration (CVD), variable volume diafiltration (VVD) and intermittent feed diafiltration (IFD) modes. 19 Several parameters may have a pronounced influence on the diafiltration mode process, such as rejection coefficient, permeation factor, volume dilution ratio and volume concentration ratio.…”

Section: Introductionmentioning

confidence: 99%

“…12,17,20 Nevertheless, modeling plays an important role in how to use the proper parameters with clear physical meaning to describe and clarify the whole diafiltration process. 16,21 There is no report in the literature dealing with the purification of lactulose syrup catalyzed by sodium aluminate. In this study, pH-induced precipitation and centrifugation followed by ion exchange treatment regarding catalyst removal were implemented in sequence.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Preparation of high‐purity lactulose through efficient recycling of catalyst sodium aluminate and nanofiltration: a pilot‐scale purification

et al. 2018

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Section: Cvd and Vvd Modes For Purification Of Lactulose Syrupmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation of high‐purity lactulose through efficient recycling of catalyst sodium aluminate and nanofiltration: a pilot‐scale purification

et al. 2018

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“…It has been widely used to separate or purify sugars [ 11 , 12 ] and oligosaccharides [ 13 , 14 , 15 , 16 , 17 , 18 ] from mixtures of carbohydrates. However, the separation is generally based primarily on a difference in size, and therefore cannot be used to separate sugars or isomers that have similar properties and are of similar size [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Separation of Fructose and Glucose via Nanofiltration in Presence of Fructooligosaccharides

et al. 2020

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Fructose and glucose are commonly present together in mixtures and may need to be separated. Current separation methods for these isomers are complex and costly. Nanofiltration is a cost-effective method that has been widely used for separating carbohydrates of different sizes; however, it is not commonly used for such similar molecules. Here, we report the separation of fructose and glucose in a nanofiltration system in the presence of fructooligosaccharides (FOS). Experiments were performed using a pilot-scale filtration setup using a spiral wound nanofiltration membrane with molecular weight cutoff of 1 kDa. We observed three important factors that affected the separation: (1) separation of monosaccharides only occurred in the presence of FOS and became more effective when FOS dominated the solution; (2) better separation was achieved when the monosaccharides were mainly fructose; and (3) the presence of salt improved the separation only moderately. The rejection ratio (Rf/Rg) in a fructose/glucose mixture is 0.92. We reported a rejection ratio of 0.69, which was observed in a mixture of 50 g/L FOS with a fructose to glucose ratio of 4.43. The separation is hypothesized to occur due to selective transport in the FOS layer, resulting in a preferential binding towards fructose.

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Nanofiltration for separation and purification of saccharides from biomass

Tan

Luo

et al. 2021

Front. Chem. Sci. Eng.

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Saccharide production is critical to the development of biotechnology in the field of food and biofuel. The extraction of saccharide from biomass-based hydrolysate mixtures has become a trend due to low cost and abundant biomass reserves. Compared to conventional methods of fractionation and recovery of saccharides, nanofiltration (NF) has received considerable attention in recent decades because of its high selectivity and low energy consumption and environmental impact. In this review the advantages and challenges of NF based technology in the separation of saccharides are critically evaluated. Hybrid membrane processes, i.e., combining NF with ultrafiltration, can complement each other to provide an efficient approach for removal of unwanted solutes to obtain higher purity saccharides. However, use of NF membrane separation technology is limited due to irreversible membrane fouling that results in high capital and operating costs. Future development of NF membrane technology should therefore focus on improving material stability, antifouling ability and saccharide targeting selectivity, as well as on engineering aspects such as process optimisation and membrane module design.

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Modelling of membrane cascades for the purification of oligosaccharides

Cited by 26 publications

References 27 publications

Preparation of high‐purity lactulose through efficient recycling of catalyst sodium aluminate and nanofiltration: a pilot‐scale purification

Preparation of high‐purity lactulose through efficient recycling of catalyst sodium aluminate and nanofiltration: a pilot‐scale purification

Separation of Fructose and Glucose via Nanofiltration in Presence of Fructooligosaccharides

Nanofiltration for separation and purification of saccharides from biomass

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