This study examines the grinding process of pumice based on the dry and wet laboratory measurements, scale-up method, and life cycle assessment. This research’s main goal was to set up the relation between scale-up and life cycle assessment results for the wet grinding process with the help of mathematical equations. Within the first research works, basic grinding testing in a laboratory dry Bond mill was accomplished. This step allowed the description of the estimated particle size distribution, median particle size, specific grinding work, and grindability index number of pumice. The second step was the determination of power consumption and scale-up in a laboratory stirred media mill, and it involved the assessment of resources, primary energies, and environmental impacts of wet grinding using GaBi 8.0 software. According to the results, we obtain life cycle emission factors by introducing five coefficients for grinding in laboratory and industrial conditions. These constants depend on the external dimensions of the mill and can be expressed by a derived scale constant from the scale-up. Research results enable the industry to make a prognosis for industrial plants based on the integration between life cycle assessment and scale-up of the pilot grinding processes.