Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats

Abstract

Myocardial infarction (MI) has been associated with increases in reactive oxygen species (ROS). Exercise training (ET) has been shown to exert positive modulations on vascular function and the purpose of the present study was to investigate the effect of moderate ET on the aortic superoxide production index, NAD(P)H oxidase activity, superoxide dismutase activity and vasomotor response in MI rats. Aerobic ET was performed during 11 weeks. Myocardial infarction significantly diminished maximal exercise capacity, and increased vasoconstrictory response to norepinephrine, which was related to the increased activity of NAD(P)H oxidase and basal superoxide production. On the other hand, ET normalized the superoxide production mostly due to decreased NAD(P)H oxidase activity, although a minor SOD effect may also be present. These adaptations were paralleled by normalization in the vasoconstrictory response to norepinephrine. Thus, diminished ROS production seems to be an important mechanism by which ET mediates its beneficial vascular effects in the MI condition.

Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

“…Regarding physical activity, it has been described that exercise training diminished production of reactive oxygen species in rats [30]. Moreover, another study showed an increased activity of glutathione peroxidase in erythrocytes although serum Se did not change between active and sedentary elderly subjects [31].…”

Additive Beneficial Effects of Lactotripeptides Intake With Regular Exercise on Endothelium-Dependent Dilatation in Postmenopausal Women

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Cardiovascular Effects of Exercise Training

“…In animal and human studies, exercise training programs resulted in an increased vascular expression of antioxidative enzymes, such as SOD, catalase, and glutathione peroxidase [133][134][135] and a reduced expression of ROS-generating enzymes such as nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase and xanthine oxidase. 94,136 Nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase expression and activity are regulated mainly by the dominant influence of angiotensin II type 1 receptor activation by inducing a rapid rac1 translocation to the cell membrane. 137 In addition, a 4-week exercise training program in patients with coronary artery disease resulted in a significantly lower expression of angiotensin II type 1 receptor compared with a sedentary control group.…”