Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women

Abstract

Objectives Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome. Therefore, lifestyle modification through a nonpharmacological approach based on physical exercise is the right strategy in lowering betatrophin levels. This study aimed to analyze the effect of moderate-intensity interval and continuous exercises on decreased betatrophin levels and the association between betatrophin levels and obesity markers in women. Methods A total of 30 women aged 20–24 years old were randomly divided into three groups. Measurement of betatrophin levels using Enzyme-Linked Immunosorbent Assay (ELISA). Data analysis techniques used were one-way ANOVA and parametric linear correlation. Results The results showed that the average levels of betatrophin pre-exercise were 200.40 ± 11.03 pg/mL at CON, 203.07 ± 42.48 pg/mL at MIE, 196.62 ± 21.29 pg/mL at MCE, and p=0.978. Average levels of betatrophin post-exercise were 226.65 ± 18.96 pg/mL at CON, 109.31 ± 11.23 pg/mL at MIE, 52.38 ± 8.18 pg/mL at MCE, and p=0.000. Pre-exercise betatrophin levels were positively correlated with age, BMI, FM, WHR, FBG, and PBF (p≤0.001). Conclusions Our study showed that betatrophin levels are decreased by 10 min post-MIE and post-MCE. However, moderate-intensity continuous exercise is more effective in lowering betatrophin levels than moderate-intensity interval exercise. In addition, pre-exercise betatrophin levels also have a positive correlation with obesity markers.

Moderate-intensity Exercise Decreases Cortisol Response in Overweight Adolescent Women

“…Strength training is performed intensively with an intensity of 60-70% HRmax for 40 minutes with details of 5 minutes warm-up with an intensity of 50-60% HRmax, 30 minutes of the main exercise perform continuous exercise with an intensity of 6070% HRmax and 5 min of cooling with an intensity of 50-60% HRmax . Exercise was performed from 07:00 to 09:00 on a treadmill (Pulsar 4.0 HP Cosmos Sports & Medical, Nuss-dorfTraunstein, Germany) (Nedić et al, 2017;Rejeki et al, 2022). Heart rate monitoring during exercise using a Polar heart rate monitor (Polar Heart Rate Sensor H10, Inc., USA) (Rejeki et al, 2022).…”

The comparison of the effect of acute moderate and high-intensity exercise on the uncoupling protein -1 secretion

“…The exercise was completed by running on a treadmill for 40 minutes (Rejeki et al, 2021;Rejeki et al, 2022;Andarianto et al, 2022) with a highintensity (75-85% HRmax) and moderate-intensity (65-75% HRmax).…”

Betatrophin and Insulin Resistance

“…This effect was achieved by body fat reduction, but not by physical activity [ 59 ]. The research of Purwo [ 60 ] illustrated that the level of betatrophin declined at 10 min after moderate interval training and moderate continuous training, and this decline was more evident at 10 min after moderate continuous training. In addition, the level of betatrophin before exercise also appeared to be positively correlated with obesity-related markers.…”