Modern fixed combinations of antihypertensive drugs in the treatment of arterial hypertension and obesity: can this comorbid pathology be effectively controlled?

Васюк, Ю. А.; Шупенина, Е. Ю.; Ющук, Е. Н.; Намазова, Г. А.

doi:10.15829/1560-4071-2019-9-14-21

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…результаты регистра рекваЗа (регистр кардиоваскулярных Заболеваний) с участием 3690 больных в возрасте 66,1 года c аГ, иБс, хсН, фибрилляцией предсердий и их сочетаниями также показали, что у больных с ранним развитием ссЗ значимо чаще выявлялось ожирение [22]. аналогичные данные представлены в работах и других исследователей [23][24][25].…”

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Problems of insufficient control of target blood pressure levels in the outpatient practice

Ларина

Fedorova

Михайлусова

et al. 2021

Terapevticheskii arkhiv

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Aim. Assessment of the frequency of reaching the target level of blood pressure (BP) and the factors affecting it in outpatients with arterial hypertension (AH). Materials and methods. An open, one-stage, comparative study involving 64 patients with hypertension and 47 without hypertension at the age of 40 to 59 years. All patients underwent physical examination, assessment of cardiovascular risk (CVR), 24-hour blood pressure monitoring (ABPM), echocardiography (ECHOCG), color duplex scanning of brachiocephalic arteries. Results. Patients with hypertension and comparison groups were comparable in age, sex, smoking, history of myocardial infarction. 1st degree of hypertension was present in 26.6%, 2nd in 40.6%, 3rd in 12.5% of patients. Obesity was detected in 24.3% of patients and all patients with obesity had AH. The SCORE score in individuals with hypertension was 4.94.5; in the comparison group, 2.32.6 (p0.001). Non-stenosing atherosclerosis was present in 54.8% and 88%, p=0.020, and atherosclerotic plaque in the vascular lumen was present in 45.3% and 12% of patients with and without hypertension, respectively (p0.001). 68.8% were constantly treated, and the target BP was reached in 31.3% of patients with hypertension. Male gender (OR 1.68; 95% CI 1.6828.49; p=0.007), obesity (OR 4.78; 95% CI 1.1420.29; p=0.033), concomitant pathology (OR 3.09; 95% CI 1.029.37; p=0.046) were negative, and dyslipidemia (OR 0.10; 95% CI 0.010.84; p=0.033) was positive, affecting the achievement of the target level of blood pressure. Conclusion. The target level of blood pressure was achieved in 31.3% of outpatients with hypertension, mainly in women. Among patients who did not reach the target level of blood pressure, men, individuals with high SSR and obesity predominated. Concomitant pathology and obesity are negative, and dyslipidemia was positively associated with the achievement of the target level of blood pressure, which must be taken into account when developing measures for prevention and treatment.

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Section: ðåçóëüòàòûunclassified

Problems of insufficient control of target blood pressure levels in the outpatient practice

Ларина

Fedorova

Михайлусова

et al. 2021

Terapevticheskii arkhiv

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The role of risk factors and genetic polymorphism in assessing the effectiveness of combined antihypertensive therapy in a small population of shor people

Мулерова¹,

Цыганкова²,

Chigisova³

et al. 2021

Profil. med.

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Clinical, nutritional, anthropometric indicators and frequency of occurrence of Ala16Val (rs4880) polymorphic locus of the <i>MnSOD</i> gene in vibration disease comorbid with arterial hypertension

Gorbunova,

Gerasimenko,

Shpagin

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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The continuing interest in the problem of vibration disease (VD), especially when combined with arterial hypertension (AH), is due to the steady development of industrial sectors associated with vibration acceleration and the tendency towards the early development of AH. Aim of the study was to investigate the features of clinical, nutritional and anthropometric indicators and frequency of occurrence of Ala16Val (rs4880) polymorphic locus of the manganese superoxide dismutase (MnSOD) gene in VD combined with AH. Material and methods. 431 people were examined, among them 104 patients with VD stage I, 101 – with VD stage I in combination with AH I–II stage, 107 – with AH I–II stage, without contact with vibration, and 119 people working at the same enterprise without contact with vibration, without signs of hypertension. A complex of clinical, anthropometric, laboratory, functional and genetic studies has been carried out. Results. In case of VD comorbid with AH, the frequency of complaints, both general and specific, significantly increases compared to other groups. Body mass index, waist circumference / hip circumference (WC/HC) ratio, fat mass increase, extracellular fluid content with a decrease in active cell mass, musculoskeletal mass and phase angle compared with the control group. An imbalance of nutrition in terms of macro- and micronutrients, an increased content of the fat component in the diet with a deficiency in the diet of omega-3 polyunsaturated fatty acids has been established. In persons with VD and AH, the C/C genotype, which is more common in healthy people, is registered in only 16% of cases, while the polymorphic variant T/T is in 29 %, which exceeds the corresponding value in the control and isolated AH groups by 1.9 and 1.5 times, respectively. Discussion. The common pathogenetic features of VD and AH lead to the development of adipose tissue dysfunction and trophological insufficiency. There is no doubt that hypertension is associated with increased body weight, obesity, and adipocytokine serum concentration. An indicator of a high risk of developing cardiovascular pathology, including heart attack, stroke, is an increase in the WC/HC index. The role of the Ala16Val polymorphism of the MnSOD gene in the formation of AH and some variants of occupational diseases has been shown in a number of studies. Conclusions. The variant of VD, comorbid with AH, is characterized by a significant increase in the frequency of detection of the T/T genotype in the polymorphic locus Ala16Val (rs4880) of the MnSOD gene in combination with an altered nutritional and anthropometric status of such patients. The presence of this polymorphism may be associated with an increased risk of developing concomitant vascular pathologies in VD, however, in combination with malnutrition and associated changes in anthropometric parameters, this risk increases many times over. Thus, early diagnosis of the risk of developing comorbid vascular pathology in VD can be aimed at identifying the genotype, and prevention can be aimed at modifying nutrition.

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Modern fixed combinations of antihypertensive drugs in the treatment of arterial hypertension and obesity: can this comorbid pathology be effectively controlled?

Cited by 3 publications

References 9 publications

Problems of insufficient control of target blood pressure levels in the outpatient practice

Problems of insufficient control of target blood pressure levels in the outpatient practice

The role of risk factors and genetic polymorphism in assessing the effectiveness of combined antihypertensive therapy in a small population of shor people

Clinical, nutritional, anthropometric indicators and frequency of occurrence of Ala16Val (rs4880) polymorphic locus of the <i>MnSOD</i> gene in vibration disease comorbid with arterial hypertension

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