Modern possibilities of laboratory diagnosis of disorders of the gastrointestinal tract

Хавкин, А.И.; Гурина, О. П.; Дементьева, Е. А.; Блинов, Александр Евгеньевич; Варламова, Ольга Николаевна

doi:10.31146/1682-8658-ecg-178-6-173-185

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…Мотилин расширяет сосуды желудка, способствует запуску желудочных мигрирующих моторных комплексов, регулирует моторику желудочно-кишечного тракта в перерывах между приемами пищи [21,22]. Он является полипептидом, содержащим 22 аминокислоты [23], и секретируется в период голодания энтерохромафинными клетками, расположенными в толще слизистой антрального отдела желудка, двенадцатиперстной, тощей и сигмовидной кишок [24,25]. Изменения в количественном и качественном составе секретирующих мотилин клеток в слизистой оболочке желудочно-кишечного тракта коррелируют с клинической симптоматикой при функциональной гастроинтестинальной патологии [26].…”

Section: резюмеunclassified

“…При этом физиологически вскоре после приема пищи должно наблюдаться падение концентрации мотилина в крови. Ее увеличение способствует расширению сосудов желудка и запуску желудочных мигрирующих двигательных комплексов [22], что клинически может проявляться спастической болью [25], характерной для пациентов с СБЭ. Высокий уровень мотилина в плазме крови при СБЭ был выявлен и другими исследователями [27].…”

Section: результаты и обсуждениеunclassified

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Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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Purpose of the study: to clarify the effect of the concentration of motilin in the blood on the clinical symptoms of functional dyspepsia. Materials and methods. A prospective examination of 90 people aged 22,3±0,17 years was carried out, divided into 3 groups: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. All subjects were questioned according to the GSRS questionnaire, and the concentration of motilin in their blood was determined before and after the drinking test. Statistical processing included the calculation of mean values, their errors, Student’s t-test, Pearson’s correlation test, factor analysis. Results. In patients with PDS, the intensity of abdominal pain (2,47±0,38 points) does not differ from healthy ones (2,19±0,22 points), in patients with EPS it is higher (4,33±0,51 points). Dyspeptic syndrome is more typical for patients with PDS (2,07±0,12 points) than for EPS (1,10±0,04 points). The concentration of motilin in the blood on an empty stomach with PDS (9605,47±167,64 pg/ml) is higher than with EPS (8780,67±232,27 pg/ml). After the drinking test, the level of motilin in the blood of patients with EPS increased to 9367,33±145,78 pg/ml, the PDS decreased to 9323,33±239,04 pg/ml. With PDS, the severity of reflux syndrome directly correlates with the concentration of motilin in the blood. In EPS, the initial level of motilin correlates inversely with the severity of reflux syndrome, constipation syndrome, and the volume of water drunk. After the drinking test, there is an inverse correlation between the level of motilin and the severity of diarrheal and dyspeptic syndromes, and a direct correlation with the intensity of abdominal pain. The initial level of motilin in the blood brings the greatest factor load into the “factor of motor disorders”. Conclusion. The initial level of motilin and its dynamics during water load play an essential role in the formation of the clinical picture of functional dyspepsia.

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Section: резюмеunclassified

Section: результаты и обсуждениеunclassified

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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“…DON affects the neuroendocrine regulator of satiety and food intake, pituitary adenylate cyclase-activating polypeptide (PACAP). This polypeptide acts as a specific neurotransmitter that is synthesized by the organs of the digestive tract and may have diagnostic value [8]. Decreased appetite and increased expression of PACAP genes, associated with the ingestion of deoxynivalenol (DON), act as a defense mechanism to reduce the ingestion of mycotoxin-infected feed.…”

Section: Introductionmentioning

confidence: 99%

Environmental assessment of the use of biologically active substances of forage plants in fish farming

Chechkova

2024

BIO Web Conf.

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This article focuses on the environmental assessment of the use of biologically active substances (BAS) of forage plants in fish farming. The main attention is given to the study of the degree of microbial contamination of plant components included in the feed. The objective of the study was to identify the spectrum of contamination of grower feeds for rainbow trout with micromycetes. Due to an environmental assessment of feed samples containing forage plants (soy bean, rapeseed, wheat) or their components (soybean flour, sunflower meal), representatives of three genera of micromycetes, such as Aspergillus, Fusarium, and Rhizopus, belonging to the kingdom of Fungi, divisions Ascomycota and Zygomycota; subclasses Eurotiomycetidae, Sordariomycetidae, and Mucorineae; orders Eurotiales, Hypocreales, Mucorales, and families Trichocomaceae, Nectriaceae, and Rhizopodaceae, were found. The detrimental effect of myxomycetes on the bodies of fish has been detected.

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“…Авторы отмечают, что большая часть тест-систем пока используются только для научных целей. В перспективе предполагается внедрение данных лабораторных маркеров функциональных нарушений в медицинскую практику [10].…”

Section: Introductionunclassified

Magnetic resonance imaging with a stress drinking test as a method of assessing the evacuation function of the stomach

Shklyaev

Максимов

Panteleev

2023

jour

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Aim: to study opportunity of research the evacuation function of the stomach in young people by magnetic resonance imaging with a stress drinking test. Materials and methods: the study group included 20 young people (10 men and 10 women aged 23 ± 1,12 years). At the time of the study, each test person excluded organic and functional pathologies of the gastroduodenal zone. A method of magnetic resonance imaging of the stomach with a stress drinking test (still drinking water at room temperature with a volume of 1000.0 ml) was used. The examination lasted 30 minutes, scanning was carried out every 5 minutes, a total of 7 scans. Based on the obtained three-dimensional images of the DICOM format using the HorosMobile™ application (DICOM medical image viewer), the volumes of fluid in the stomach in dynamics were calculated for each test person in the study group according to the time intervals of the scans performed by the magnetic resonance imaging machine. Systematization and data processing were carried out a Microsoft Excel. A single graph was built for the study group in the Pages graphical editor (iWork productivity suite) based on the obtained data, reflecting the reference volumes of gastric contents relative to the time scale with possible deviations from the average. Results: regardless of the type of physique and shape of the stomach in the studied subjects, the evacuation of a larger volume of fluid (81,53-82,54%) occurred by the 15th minute of the study. Complete evacuation of gastric contents occurs between 25 and 30 minutes of the study. Conclusions: the results obtained by MRI studies of the stomach with a stress drinking test give an idea of the options for normal physiological evacuation of gastric contents in young people, in the absence of organic and functional pathology of the gastroduodenal zone.

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Modern possibilities of laboratory diagnosis of disorders of the gastrointestinal tract

Cited by 5 publications

References 31 publications

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Environmental assessment of the use of biologically active substances of forage plants in fish farming

Magnetic resonance imaging with a stress drinking test as a method of assessing the evacuation function of the stomach

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