Coarse-grain heat-affected zone (CGHAZ) properties of steel deteriorate when it is welded using high heat input, which always restricts the promotion and use of high heat input welding steel. TiN particles significantly inhibit the growth of austenite and improve the microstructure and properties of high heat input welding steel. Effects of different Ti/N ratios on the CGHAZ microstructure and properties of high heat input welding steel were studied using welding thermal simulations and in situ observations. Results showed that a higher Ti/N ratio led to the abnormal growth of austenite grains and promoted the nucleation and growth of lath ferrite, which made the microstructure of the CGHAZ heterogeneous. In contrast, austenite grains were more uniform at a lower Ti/N ratio. Thus, the microstructure was refined, the brittle structure was reduced, and the properties of the CGHAZ were improved. In addition, when Ti/N = 5.85, the impact absorption energy of the CGHAZ obviously fluctuated. However, when Ti/N = 2.82, the impact absorption energy of the CGHAZ was higher and more stable. These results provided a new idea for the development of high heat input welding steel based on TiN theory.