Modification of Biomaterials to Improve Blood Compatibility

Ch, Bamford; Ip, Middleton; Kg, al-Lamee; Jj, Paprotny

doi:10.1177/039139889201500202

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…It is well-known that the physicochemical properties and biological behavior of polymeric systems depend on the microstructural characteristics of their macromolecular chains which are constructed during the polymerization process by any of the established mechanisms of reaction. [1][2][3][4][5][6] This is particularly important in the case of free radical copolymerization reactions when monomers of very different chemical structure and reactivity participate.…”

Section: Introductionmentioning

confidence: 99%

In Situ Quantitative ¹H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

et al. 2002

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The copolymerization reactions of acrylic systems of biomedical interest, 2-hydroxyethyl methacrylate (HEMA)/2-acrylamido-2-methylpropanesulfonic acid (AMPS) and N,N-dimethylacrylamide (DMAA)/AMPS, have been analyzed by 1H NMR. A new methodology is described for the determination of the reactivity ratios based on the quantitative in situ NMR analysis in the course of the copolymerization reaction. The methodology uses the continuous change of the intensity of resonance signals assigned unambiguously to the monomers participating in the polymerization reaction with the reaction time at a given temperature. The evaluation of the monomer concentrations leads to the determination of the instantaneous feed molar fractions and the reactivity ratios, by using a solution of the differential copolymerization equation which describes the terminal model described by Mayo and Lewis. Two approaches to obtain the reactivity ratios by nonlinear fitting of the experimental data to this integrated form are described. The first incorporates the initial conditions as third parameter in the optimization (the values obtained are r HEMA = 6.81 and r AMPS = 0.116 for the HEMA−AMPS system and r DMAA = 1.50 and r AMPS = 0.40 for DMAA−AMPS), and the second uses different points as initial conditions in the integrated equation (obtaining r DMAA = 1.53 and r AMPS = 0.36, in very good agreement with the obtained by the first method). These values are in good agreement with those described in the literature and with data for copolymers prepared at low conversion analyzed by standard methods.

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Section: Introductionmentioning

confidence: 99%

In Situ Quantitative ¹H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

et al. 2002

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“…Platelet adhesion and activation on material surfaces may lead to blood coagulation and thrombosis, which is sometimes life‐threatening or may cause functional failure in the applications of artificial organ implantations, manmade blood vessels, and other blood‐contacting medical devices 1–3. To solve this problem, numerous approaches have been developed to fabricate more blood‐compatible materials,4 such as mimicking the nonthrombogenic endothelial cell5 and chemical modification 6. However, these methods strongly rely on chemical synthesis or biological treatments, which are sometimes very limited and confined to specific materials.…”

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confidence: 99%

No Platelet Can Adhere—Largely Improved Blood Compatibility on Nanostructured Superhydrophobic Surfaces

Sun

Tan

Han

et al. 2005

Small

295

214

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It won't stick! Aligned carbon nanotube films were used as templates in the dip coating of polymers for biomedical applications. The resulting nanostructured polymeric surfaces have excellent anti‐adhesion to blood platelets, good blood compatibility, and superhydrophobicity. The SEM image shows the side view of a film coated with a fluorinated poly(carbonate urethane); inset: a water drop profile.

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“…They can be generally categorized into methods based on (1) mimicking nonthrombogenic endothelial cells (EC) [126–130] which line the inner walls of all healthy blood vessels and (2) use of chemical surface moieties that suppress blood-material interactions (e.g., polymeric surfaces that exhibit decreased protein and cell adhesion). Adsorption of proteins (especially fibrinogen and von Willebrand's factor) is the first step in the overall process by which blood contacting materials can activate platelets, which leads eventually to thrombus formation on or near the surface of the implanted device.…”

Section: Platelet Adhesion and Functionmentioning

confidence: 99%

Obstacles in Haemocompatibility Testing

Oeveren¹

2013

Scientifica

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ISO 10993-4 is an international standard describing the methods of testing of medical devices for interactions with blood for regulatory purpose. The complexity of blood responses to biomaterial surfaces and the variability of blood functions in different individuals and species pose difficulties in standardisation. Moreover, in vivo or in vitro testing, as well as the clinical relevance of certain findings, is still matter of debate. This review deals with the major remaining problems, including a brief explanation of surface interactions with blood, the current ISO 10993 requirements for testing, and the role of in vitro test models. The literature is reviewed on anticoagulation, shear rate, blood-air interfaces, incubation time, and the importance of evaluation of the surface area after blood contact. Two test categories deserve further attention: complement and platelet function, including the effects on platelets from adhesion proteins, venipuncture, and animal derived- blood. The material properties, hydrophilicity, and roughness, as well as reference materials, are discussed. Finally this review calls for completing the acceptance criteria in the ISO standard based on a panel of test results.

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Modification of Biomaterials to Improve Blood Compatibility

Cited by 8 publications

References 20 publications

In Situ Quantitative ¹H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

In Situ Quantitative ¹H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

No Platelet Can Adhere—Largely Improved Blood Compatibility on Nanostructured Superhydrophobic Surfaces

Obstacles in Haemocompatibility Testing

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Modification of Biomaterials to Improve Blood Compatibility

Cited by 8 publications

References 20 publications

In Situ Quantitative 1H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

In Situ Quantitative 1H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

No Platelet Can Adhere—Largely Improved Blood Compatibility on Nanostructured Superhydrophobic Surfaces

Obstacles in Haemocompatibility Testing

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Product

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About

In Situ Quantitative ¹H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios

In Situ Quantitative ¹H NMR Monitoring of Monomer Consumption: A Simple and Fast Way of Estimating Reactivity Ratios