Modification of chitosan using amino acids for wound healing purposes: A review

Torkaman, Sara; Rahmani, Hossein; Ashori, Alireza; Najafi, Seyed Heydar Mahmoudi

doi:10.1016/j.carbpol.2021.117675

Cited by 88 publications

(42 citation statements)

References 93 publications

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“…Additionally, the COO- symmetric and asymmetric stretching can be seen at the spectral band of ~1530 cm −1 in all spectra and an additional peak at 1402 cm −1 in Mn:ZnS. The peak at 1402 is disappearing in MMC@CS-Mn:ZnS sample and might be due to the formation of nanocomposites that involve the binding of carboxyl group (COO–) of Mn:ZnS with the amino group (–NH 2 ) of CS [ 44 ], as the amine group of CS supports electrostatic interaction to produce a stable mixture [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Drug Release Profiles of Mitomycin C Encapsulated Quantum Dots–Chitosan Nanocarrier System for the Possible Treatment of Non-Muscle Invasive Bladder Cancer

et al. 2021

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Nanotechnology-based drug delivery systems are an emerging technology for the targeted delivery of chemotherapeutic agents in cancer therapy with low/no toxicity to the non-cancer cells. With that view, the present work reports the synthesis, characterization, and testing of Mn:ZnS quantum dots (QDs) conjugated chitosan (CS)-based nanocarrier system encapsulated with Mitomycin C (MMC) drug. This fabricated nanocarrier, MMC@CS-Mn:ZnS, has been tested thoroughly for the drug loading capacity, drug encapsulation efficiency, and release properties at a fixed wavelength (358 nm) using a UV–Vis spectrophotometer. Followed by the physicochemical characterization, the cumulative drug release profiling data of MMC@CS-Mn:ZnS nanocarrier (at pH of 6.5, 6.8, 7.2, and 7.5) were investigated to have the highest release of 56.48% at pH 6.8, followed by 50.22%, 30.88%, and 10.75% at pH 7.2, 6.5, and 7.5, respectively. Additionally, the drug release studies were fitted to five different pharmacokinetic models including pesudo-first-order, pseudo-second-order, Higuchi, Hixson–Crowell, and Korsmeyers–Peppas models. From the analysis, the cumulative MMC release suits the Higuchi model well, revealing the diffusion-controlled mechanism involving the correlation of cumulative drug release proportional to the function square root of time at equilibrium, with the correlation coefficient values (R2) of 0.9849, 0.9604, 0.9783, and 0.7989 for drug release at pH 6.5, 6.8, 7.2, and 7.5, respectively. Based on the overall results analysis, the formulated nanocarrier system of MMC synergistically envisages the efficient delivery of chemotherapeutic agents to the target cancerous sites, able to sustain it for a longer time, etc. Consequently, the developed nanocarrier system has the capacity to improve the drug loading efficacy in combating the reoccurrence and progression of cancer in non-muscle invasive bladder diseases.

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Section: Resultsmentioning

confidence: 99%

Drug Release Profiles of Mitomycin C Encapsulated Quantum Dots–Chitosan Nanocarrier System for the Possible Treatment of Non-Muscle Invasive Bladder Cancer

et al. 2021

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“…Due to its unique antibacterial characteristic, chitosan is one of the most studied biopolymers for wound healing. [ 35,190–193 ] Deng et al synthesized four water‐soluble thymine‐modified chitosan derivatives and developed them into porous sponge via freeze‐drying method. [ 193 ] Compared with gauze and chitosan, this sponge significantly accelerated the wound healing process.…”

Section: Application Of Polysaccharide Scaffoldsmentioning

confidence: 99%

Engineering Polysaccharides for Tissue Repair and Regeneration

et al. 2021

Macromolecular Bioscience

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The success of repair or regeneration depends greatly on the architecture of 3D scaffolds that finely mimic natural extracellular matrix to support cell growth and assembly. Polysaccharides have excellent biocompatibility with intrinsic biological cues and they have been extensively investigated as scaffolds for tissue engineering and regenerative medicine (TERM). The physical and biochemical structures of natural polysaccharides, however, can barely meet all the requirements of tissue‐engineered scaffolds. To take advantage of their inherent properties, many innovative approaches including chemical, physical, or joint modifications have been employed to improve their properties. Recent advancement in molecular and material building technology facilitates the fabrication of advanced 3D structures with desirable properties. This review focuses on the latest progress of polysaccharide‐based scaffolds for TERM, especially those that construct advanced architectures for tissue regeneration.

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“…11 Modification of CS with different amino acids was designed to enhance its antibacterial and wound healing applications. 12 Modification of CS and sodium carboxymethylcellulose by magnetic molybdenum disulfide act as promising strategy for targeted drug delivery and photothermal tumor therapy. 13 In addition, biobased CS was functionalized by substitution of its amino groups with hexanoyl chloride.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and biological activities of folic acid conjugates with polyvinyl alcohol, chitosan, and cellulose

El‐Naggar

El‐Barbary

Salama

et al. 2022

J of Applied Polymer Sci

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Polyvinyl alcohol (PVA), chitosan (CS), and cellulose (CL) are promising polymers for chemical functionalization and biomedical applications. This study aimed to synthesize folic acid (FA) conjugates with PVA, CS, and CL via chloroacetyl chloride, 2-bromopropionyl bromide, and epichlorohydrin to enhance it biomedical applications. The functionalized polymer conjugates were characterized by FT-IR, 1 H-NMR, GPC, and TGA techniques. FT-IR and 1 H-NMR revealed the main functional groups (O H, N H, C═O, C═N), the aromatic C H and N H protons of FA moieties. TGA illustrated two stages of decompositions of all-polymer conjugates. FA showed no antifungal activity, while two of the newly grafted polymer conjugates (chitosan bromopropionate-grafted FA and cellulose chloroacetate-grafted FA) illustrated antifungal activity against both Aspergillus fumigatus and Candida albicans. Polymer conjugates; poly(vinyl chloroacetate)-grafted FA and chitosan-EPCH-grafted FA revealed good antifungal effect on C. albicans and A. fumigatus, respectively. Most FA polymer conjugates showed significant antitumor activity against EAC-bearing mice. Among these conjugates, chitosan chloroacetate-grafted FA (P-2A) showed the highest antitumor effect against EAC-bearing mice via reduction in total tumor volume. Thus, these conjugates provided enhanced antifungal and antitumor activities as compared with FA itself. These conjugates may act as promising biologically active carrier systems for other applications such as drug delivery.

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Modification of chitosan using amino acids for wound healing purposes: A review

Cited by 88 publications

References 93 publications

Drug Release Profiles of Mitomycin C Encapsulated Quantum Dots–Chitosan Nanocarrier System for the Possible Treatment of Non-Muscle Invasive Bladder Cancer

Drug Release Profiles of Mitomycin C Encapsulated Quantum Dots–Chitosan Nanocarrier System for the Possible Treatment of Non-Muscle Invasive Bladder Cancer

Engineering Polysaccharides for Tissue Repair and Regeneration

Synthesis, characterization, and biological activities of folic acid conjugates with polyvinyl alcohol, chitosan, and cellulose

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