Modification of electrospun poly(ε-caprolactone) mats by formation of a polyelectrolyte complex between poly(acrylic acid) and quaternized chitosan for tuning of their antibacterial properties

Biomedical applications of electrospun polycaprolactone fiber mats

“…The coating the surface of PCL fiber mats with crosslinked PAA followed by a polyelectrolyte complex with N , N , N ‐trimethylchitosan iodide and grafting of PAA on the surface of PCL fiber mats followed by polyelectrolyte complex formation between grafted PAA and N , N , N ‐trimethylchitosan iodide was used to modify the antibacterial properties of the PCL fiber mats. The results showed that both approaches were an assuring method to prepare the antibacterial fiber mats for use in biomedical applications, especially wound dressing materials . Liao et al prepared the electrospun PCL–cellulose–dextran fiber mats containing tetracycline hydrochloride for use as wound dressings.…”

“…The results showed that both approaches were an assuring method to prepare the antibacterial fiber mats for use in biomedical applications, especially wound dressing materials. [69] Liao et al prepared the electrospun PCL-cellulosedextran fiber mats containing tetracycline hydrochloride for use as wound dressings. The results showed that addition of tetracycline hydrochloride in the electrospun fiber mats improved the cell attachment, blood clotting ability, cell proliferation and also antibacterial activity.…”

N,N,N-Trimethyl Chitosan and Its Potential Bactericidal Activity: Current Aspects and Technological Applications

“…Another electrospun nanofibers, formulated from association of poly(e-caprolactone) coated by poly(acrylic acid)/TMC iodide polyelectrolyte complex, inhibited the growth of S. aureus and E. coli, as well as, suppressed the pathogenic bacteria adhesion of S. aureus [16]. Nanoparticles containing quaternized moieties on their surfaces also suppressed the E. coli growth [24].…”

“…TMC basedmaterials (thin films, beads, thermosensitive hydrogels, polyeletrolyte complexes, nanoparticles, etc.,) may be designed as drug delivery matrices [13], as building devices coated with bactericidal and cell growth potentials [12,14] and developing biodegradable membranes [15,16] with bactericidal action for use in food industry, among others. This paper highlights the latest issues concerning TMC antimicrobial potential, as well as, some TMC-based technological applications.…”

Poly(ester amides) (PEAs) – Scaffold for tissue engineering applications

“…But the major limitation is their mechanical property. Synthetic polymers 26,27,28,29,30,31,32,33 such as poly(caprolactone) (PCL), poly(lactide), poly(ethylene oxide) (PEO), and poly(vinyl alcohol) (PVA) etc are commonly used for biomedical application including scaffolds for tissue engineering, bioabsorbable surgical sutures, and drug delivery systems 34,35,36,37,38,39,40,41 . These polymers have notable mechanical stability, high compatibility with wide range of solvents, tunable degradation property, and morphology.…”