Modification of graphene oxide by a facile coprecipitation method and click chemistry for use as a drug carrier

Xu, Guowen; Xu, Ping; Shi, Dongjian; Chen, Mingqing

doi:10.1039/c4ra02219j

Cited by 23 publications

(19 citation statements)

References 57 publications

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“…Yang's group firstly developed superparamagnetic graphene oxide-Fe 3 O 4 nanoparticles and conjugated the MG with folic acid for loading doxorubicin hydrochloride (DOX). 10,20 In order to improve the biocompatibility, a series of polymers, such as polyethylene glycol (PEG), 21 chitosan (CHI), 22 polyethylenimine (PEI), 23 poly [2-(dimethylamino) ethyl methacrylate] (PDMAEMA), 24 and so on, were employed to modify MG for loading and release of DOX and levofloxacin. However, relative low loading capacity and complicated manipulated process have confined further use.…”

Section: -3mentioning

confidence: 99%

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

Wang

Niu

et al. 2015

RSC Adv.

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β-cyclodextrin modified graphene oxide-magnetic (MGC) nanocomposite as an innovative drug carrier was the first developed via an effective layer-by-layer-assembly method. Doxorubicin hydrochloride (DOX) and epirubicin hydrochloride (EPI) as model drugs were loaded onto the MGC via π-π stacking, hydrogen bond and hydrophobic interaction. The MGC exhibits remarkably higher loading capacity for DOX (909.09 mg/g) and EPI (781.25 mg/g) than magnetic graphene oxide (MG). The release profiles of drug are pH-sensitive which would control the release in acidic cytoplasm of cancer cells. Furthermore, cellular uptake using fluorescein isothiocyanate (FITC) labeled MGC proves successful internalization of MGC into the cytoplasm of MCF-7 cells. The fluorescence images demonstrate that MGC/DOX, to a certain extent, displays a more excellent delivery and superior release than MGC/EPI, due to the chiral select function of β-cyclodextrin (β-CD). The pure MGC shows no obvious cytotoxicity while drug loaded MGC reveals significantly high potency of killing MCF-7 breast cancer cells, suggesting that multi-functionalized MGC is an efficient nanoplatform for targeted delivery and controlled release of stereoisomeric anticancer drugs for biomedical applications.

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Section: -3mentioning

confidence: 99%

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

Wang

Niu

et al. 2015

RSC Adv.

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“…A pH-dependent drug release pattern was observed, in which the anticancer drugs MTX and CPT were released around tumor tissues. Wang et al [68] improved the delivery efficacy and targeting of the drug carrier based on GO-Fe3O4 by conjugating the hybrid with FA via chitosan as a bridge, followed by loading with DOX. This is an example of the successful combination of active targeting (FA) and passive targeting (magnetic nanoparticles) strategies in drug delivery.…”

Section: Graphene and Graphene Oxide In Targeted Drug Deliverymentioning

confidence: 99%

Nanomedical applications of graphene and graphene oxide

Aleksandrzak¹,

Urbas²,

Onyszko³

et al. 2016

Nanomaterials and Regenerative Medicine

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“…In this way, the range of useful reactive groups that can be introduced to the carbon nanomaterial surface, for example, for further polymer grafting, is as large as the polymerization chemistries available in the literature, which rely on three approaches [33]: (i) grafting through, that consists of polymer chains incorporated into the superficial reactive groups through the propagation reaction; (ii) grafting from, i.e., propagation of the polymer chains from surface-attached initiators; and (iii) grafting to, or attachment of, previously synthesized polymer chains to the reactive groups. For instance, vinylic or acrylic moieties can be superficially incorporated to the nanocarbons for further grafting through radical polymerization [16,34,35], alkyl halides or alkyl trithiocarbonates can be, respectively, used in grafting from for successive atom transfer radical polymerization (ATRP) [36] or reversible addition-fragmentation chain-transfer (RAFT) [37] polymerization and azido-terminated polymers can be otherwise exploited in grafting to using click chemistry [38,39].…”

Section: Introductionmentioning

confidence: 99%

Control of pH-Responsiveness in Graphene Oxide Grafted with Poly-DEAEMA via Tailored Functionalization

et al. 2020

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Polymer-grafted nanomaterials based on carbon allotropes and their derivatives (graphene oxide (GO), etc.) are typically prepared by successive reaction stages that depend upon the initial functionalities in the nanostructure and the polymerization type needed for grafting. However, due to the multiple variables involved in the functionalization steps, it is commonly difficult to predict the properties in the final product and to correlate the material history with its final performance. In this work, we explored the steps needed to graft the carboxylic acid moieties in GO (COOH@GO) with a pH-sensitive polymer, poly[2-(diethylamino)ethyl methacrylate] (poly[DEAEMA]), varying the reactant ratios at each stage prior to polymerization. We studied the combinatorial relationship between these variables and the behavior of the novel grafted material GO-g-poly[DEAEMA], in terms of swelling ratio vs. pH (%Q) in solid specimens and potentiometric response vs. Log[H+] in a solid-state sensor format. We first introduced N-hydroxysuccinimide (NHS)-ester moieties at the –COOH groups (GO-g-NHS) by a classical activation with N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide (EDC). Then, we substituted the NHS-ester groups by polymerizable amide-linked acrylic moieties using 2-aminoethyl methacrylate (AEMA) at different ratios to finally introduce the polymer chains via radical polymerization in an excess of DEAEMA monomer. We found correlated trends in swelling pH range, interval of maximum and minimum swelling values, response in potentiometry and potentiometric linear range vs. Log[H+] and could establish their relationship with the combinatorial stoichiometries in synthetic stages.

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Modification of graphene oxide by a facile coprecipitation method and click chemistry for use as a drug carrier

Abstract: A graphene oxide based ternary composite was synthesized for targeted drug carrier.

Cited by 23 publications

References 57 publications

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

Nanomedical applications of graphene and graphene oxide

Control of pH-Responsiveness in Graphene Oxide Grafted with Poly-DEAEMA via Tailored Functionalization

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