Modification of second cancer risk after malignant melanoma by parental history of cancer

Zhang, H.; Bermejo, J Lorenzo; Sundquist, Jan; Hemminki, Kari

doi:10.1038/sj.bjc.6604489

Cited by 11 publications

(14 citation statements)

References 16 publications

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“…Young age at onset of the initial cancer may be an indication of a genetic predisposition [ 61 ]. Contrary to previously reported work [ 21 , 62 , 63 ], having a parent with cancer did not generally increase the risk of being diagnosed with a subsequent malignancy. However, analyses restricted to individuals born after 1950, showed a near 50% increase in risk when either parent had a history of cancer.…”

Section: Discussioncontrasting

confidence: 99%

New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

et al. 2014

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BackgroundSkin cancer survivors experience an increased risk for subsequent malignancies but the associated risk factors are poorly understood. This study examined the risk of a new primary cancer following an initial skin cancer and assessed risk factors associated with second primary cancers.MethodsAll invasive cutaneous malignant melanomas (CMM, N = 28 069) and squamous cell carcinomas (SCC, N = 24 620) diagnosed in Norway during 1955–2008 were included. Rates of new primary cancers in skin cancer survivors were compared to rates of primary malignancies in the general population using standardized incidence ratios (SIR). Discrete-time logistic regression models were applied to individual-level data to estimate cancer risk among those with and without a prior skin cancer, accounting for residential region, education, income, parenthood, marital status and parental cancer status, using a 20% random sample of the entire Norwegian population as reference. Further analyses of the skin cancer cohort were undertaken to determine risk factors related to subsequent cancers.ResultsDuring follow-up, 9608 new primary cancers occurred after an initial skin cancer. SIR analyses showed 50% and 90% increased risks for any cancer after CMM and SCC, respectively (p < 0.01). The logistic regression model suggested even stronger increase after SCC (130%). The highest risk was seen for subsequent skin cancers, but several non-skin cancers were also diagnosed in excess: oral, lung, colon, breast, prostate, thyroid, leukemia, lymphoma and central nervous system. Factors that were associated with increased risk of subsequent cancers include male sex, older age, lower residential latitude, being married and low education and income. Parental cancer did not increase the risk of a subsequent cancer after SCC, but was a significant predictor among younger CMM survivors.ConclusionsOur results provide information on shared environmental and genetic risk factors for first and later cancers and may help to identify individuals at high risk for subsequent cancers, which will be important as skin cancer incidence continues to rise.

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Section: Discussioncontrasting

confidence: 99%

New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

et al. 2014

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“…Among the few populationbased studies assessing the risk of second melanoma, 3,8,9 this study additionally assessed the risk of next melanoma by the number of previous melanomas, stratified by familial and sporadic cases separately, and by sex, age at diagnosis, anatomical subsite, and histologic subtype of the first melanoma. To our knowledge, the risk of next melanoma in patients with 2 or more previous melanomas stratified by familial and sporadic cases separately has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Risk of Next Melanoma in Patients With Familial and Sporadic Melanoma by Number of Previous Melanomas

et al. 2015

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“…All cancer-related deaths were stratified into MM, SPC, and other causes, including cancers defined in death certificates and non-neoplastic causes of death. Additive and multiplicative interactions of family history and risk of SPC were tested as described 11 .…”

Section: Methodsmentioning

confidence: 99%

Multiple myeloma: family history and mortality in second primary cancers

Chattopadhyay

Sud

et al. 2018

Blood Cancer Journal

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Modification of second cancer risk after malignant melanoma by parental history of cancer

Cited by 11 publications

References 16 publications

New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

Risk of Next Melanoma in Patients With Familial and Sporadic Melanoma by Number of Previous Melanomas

Multiple myeloma: family history and mortality in second primary cancers

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