Modifications Du Métabolisme Glucidique Dans Le Foie en Voie De Cancérisation Par Le Diméthylaminoazobenzène I. Recherches Au Niveau Du Cycle Du Glycogène

Meunier, Michèle; Jacob, Arlette

doi:10.1002/ijc.2910030406

Cited by 2 publications

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“…This probably represents the net result of the several changes occurring in enzymes of glycogen metabolism in this tissue (Jacob, 1968; Meunier and Jacob, 1968;Nigam et al, 1962;Reid, 1965;Weber, 1961). That the metabolic regulation of glycogen is altered in hyperplastic parenchyma is further indicated by the fact that glycogen is abnormally retained in these nodules following fasting and glucagon administration (Epstein et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Histochemical study on rat liver glycogen during dab carcinogenesis

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Daoust

1970

Intl Journal of Cancer

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Section of normal rat liver stained with toluidine blue. RNA staining is slightly more intense in cells around portal spaces (ps) than around the central veins (cv). x93. FIGURE 2Adjacent section stained by the PAS reaction. Glycogen staining is slightly more intense in centrolobular areas than in periportal areas. x 93. FIGURE 3Liver section from a rat fed DAB for 30 days. Toluidine blue staining reveals a loss of RNA in centrolobular areas (delimited by broken lines). ~9 3 . FIGURE 4Adjacent section stained by the PAS reaction. A loss of glycogen occurs in centrolobular hypobasophilic parenchyma. x 93. FIGURE 5Liver section from a DAB-fed animal, toluidine blue staining. Hyperplastic nodules and trabeculae of bile ducts and connective tissue. x 93. FIGURE 6Adjacent section, PAS reaction. Glycogen stains intensely in hyperplastic nodules; trabeculae are negative.x 93. FIGURE ILiver section from DAB-fed rat, tohidine blue staining. A hyperbasophilic focus, developing from nodular parenchyma, is shown on the left. x 230. FIGURE 8Adjacent section, PAS reaction. Absence of glycogen in hyperbasophilic focus, intense staining of surrounding parenchyma. x 230. FIGURE 9Liver section from DAB-fed rat, toluidine blue staining. A portion of a tumor mass is shown on the left. x 230. FIGURE 10Gdjacent section, PAS reaction. Absence of glycogen in hepatoma cells, strong positive reaction given by surrounding tissue. x 230.

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Section: Discussionmentioning

confidence: 99%

Histochemical study on rat liver glycogen during dab carcinogenesis

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Daoust

1970

Intl Journal of Cancer

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Modifications Du Métabolisme Glucidique Dans Le Foie en Voie De Cancérisation Par Le Diméthylaminoazobenzène Ii. Modification De l'IMPORTANCE De La Voie Embden‐meyerhof

Jacob¹

1968

Intl Journal of Cancer

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In an attempt to find an explanation for the increasing hypoglycaemia observed during DAB-induced cancer invasion of hepatic tissue, we measured the activities of key enzymes of the Embden-Meyerhof pathway-i.e. glucokinase, phosphofructokinase, and pyrubate kinase. All these activities diminished in absolute terms.A comparison of glucokinase and phosphofructokinase activities, on the one hand, with those of glucose-6-phosphatase and fructose-l,6-diphosphatase, on the other, revealed that glucide breakdoan progressively outstrips glucide formation during cancer invasion.Furthermore, a larger proportion of the glucides makes use of the pentose phosphate pathway. The significance of this finding is discussed.Au cours de nos recherches, l'hypoglycemie nous est apparue conime une caracteristique de I'animal porteur d'hepatome (Jacob, 1967), et il nous a semble interessant de rechercher les raisons de cette anomalie.Parmi les diverses causes de ce dereglement, nous avons envisage I'utilisation accrue du glucose pour faire face aux besoins Cnergetiques de la cellule, ce qui se traduit par une plus grande activite de la voie Embden-Meyerhof. On sait en effet depuis Warburg et Minami (1923) que la formation d'acide lactique est plus &levee dans les cellules cancereuses que dans les cellules nor-males; toutefois I'augmentation de ce seul metabolite ne saurait Ctre confondu avec une stirnulation de la voie glycolytique. En effet, I'acide pyruvique dont provient I'acide lactique a de nombreuses utilisations dans la cellule; il peut, apres transformation en acetyl CoA, Ctre utilisk pour le cycle de Krebs ou pour la synthese des lipides; la diminution de l'une ou I'autre de ces voies peut donc entrainer une plus forte production de I'acide lactique pour une mCme quantite d'acide pyruvique forme, c'est-a-dire pour une mCme activite des enzymes de la voie Embden-Meyerhof.

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Modifications Du Métabolisme Glucidique Dans Le Foie en Voie De Cancérisation Par Le Diméthylaminoazobenzène I. Recherches Au Niveau Du Cycle Du Glycogène

Cited by 2 publications

References 13 publications

Histochemical study on rat liver glycogen during dab carcinogenesis

Histochemical study on rat liver glycogen during dab carcinogenesis

Modifications Du Métabolisme Glucidique Dans Le Foie en Voie De Cancérisation Par Le Diméthylaminoazobenzène Ii. Modification De l'IMPORTANCE De La Voie Embden‐meyerhof

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