Modified calanolides incorporated with furan-2-nitro mimics against Mycobacterium tuberculosis

Liu, Zijie; Guo, Xiaoyong; Liu, Gang

doi:10.1016/j.bmcl.2015.01.046

Cited by 14 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Calanolide B (2) + --+ [187] --Praeruptorin A (26) -+ + + [188] + [189] + Praeruptorin C (73) -+ + [190] --+ Suksdorfin (18) + ---+ [191] + 4-phenylcoumarins + [192] + [193] + [75] + + [194] + Capillarin (82) -+ -+ [195] --This table is used to list what kinds of pharmacological effects coumarin monomers correspondingly have, "+" means yes, "-" means no or unknown.…”

Section: The Electronic and Steric Effectmentioning

confidence: 99%

Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure–Activity Relationships

Zhu

Jiang

2018

Molecular Nutrition Food Res

126

View full text Add to dashboard Cite

Coumarins are fused benzene and pyrone ring systems with a wide spectrum of bioactivities, including antitumor, anti-inflammation, antiviral, and antibacterial effects. In this paper, the current development of coumarin-based drugs is introduced, and their structure-activity relationship is discussed by reviewing the relevant literature published in the past 20 years. Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification. The ortho-phenolic hydroxyl on the benzene ring has remarkable antioxidant and antitumor activities. Coumarins with aryl groups at the C-4 position have good activities in anti-HIV, antitumor, anti-inflammation, and analgesia. C-3 phenylcoumarins have strong anti-HIV and antioxidant effects. Tetracycline pyranocoumarins can significantly inhibit HIV; osthol structural analogues have antimicrobial activity. Praeruptorin C and its derivatives play an important role in lowering blood pressure and dilating coronary arteries, and khellactone derivatives have significant inhibitory effects on AIDS, cancer, and cardiovascular diseases. It is concluded that the specific site on the core structure of coumarin exhibits one or more activities due to the electronic or steric effects of the substituents. This review is intended to be conducive to rational design and development of more active and less toxic agents with a coumarin scaffold.

show abstract

Section: The Electronic and Steric Effectmentioning

confidence: 99%

Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure–Activity Relationships

Zhu

Jiang

2018

Molecular Nutrition Food Res

126

View full text Add to dashboard Cite

show abstract

“…[11][12][13] Some natural products with benzofuran scaffold display a variety of biological activities like anti-inflammatory, antibacterial, antitumor, antitubercular activities. [14][15][16][17] Some benzodifuran derivatives shows various biological activities like antimicrobial, 18 antifeedant 19 and anti-inflammatory. 20 Heterocyclic nuclei when coupled with different substituents in different reaction sequesces like Buchwald, Suzuki, peptide, oxidation or reduction reactions results novel heterocycles show variety of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Screening of 5-(Substituted Phenyl)-N-(2-Oxo-2-(Substituted Phenyl)ethyl)-N-Methylfuran-2-Sulfonamide Derivatives

Desmukh¹,

Pawar²,

Pansare³

et al. 2019

ECB

View full text Add to dashboard Cite

We synthesized substituted furansulfonamide compounds and developed reaction conditions for a series of 5-(substituted phenyl)-N-(2oxo-2-(substituted phenyl)ethyl)-N-methylfuran-2-sulfonamide derivatives (4a-4m). We have optimized methodology for targets from milligram scale to multi gram scale. The structure of synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, LCMS and purity was checked by HPLC. All the synthesized final compounds (4a-4m) are screened for antimicrobial activity (minimum inhibitory concentration) against a series of strains of Bacillus subtillis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity. The results of antimicrobial screening data revealed most of compounds (4a-4m) showed moderate to promising microbial inhibitions.

show abstract

New potential drug leads against MDR-MTB: A short review

Gatadi

Nanduri

2020

Bioorganic Chemistry

View full text Add to dashboard Cite

Modified calanolides incorporated with furan-2-nitro mimics against Mycobacterium tuberculosis

Cited by 14 publications

References 14 publications

Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure–Activity Relationships

Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure–Activity Relationships

Synthesis and Antimicrobial Screening of 5-(Substituted Phenyl)-N-(2-Oxo-2-(Substituted Phenyl)ethyl)-N-Methylfuran-2-Sulfonamide Derivatives

New potential drug leads against MDR-MTB: A short review

Contact Info

Product

Resources

About