Modified penetrating keratoplasty with Acell^® bioscaffold implant in seven horses with deep full‐thickness corneal stromal abscess

Abstract

This technique is a viable option for treatment of equine SA requiring PK. The use of bioscaffold implant is an alternative to frozen and fresh donor cornea transplantation.

Corneoconjunctival transposition with and without ACell®for deep corneal ulcer repair in 18 dogs

“…This case series demonstrated the use of a corneoconjunctival transposition in conjunction with ACell ® to repair deep or perforated corneal ulcers. Several successful surgical methods for corneal ulcer repair have been reported in the literature, including conjunctival pedicle grafts, [6][7][8][9][10] porcine bioscaffolding matrixes, 7,[11][12][13][14][15][16] amniotic membrane transplantation, 17,18 bovine pericardium, 19 and heterologous keratoplasty. [20][21][22] The goals for surgery are to provide tectonic support and preserve vision, with a clear optical medium.…”

“…[2][3][4][5] As deep corneal ulcers can progress to perforation and lead to potential vision loss, surgical correction of deep corneal ulcerations or perforations is required to provide tectonic support, maintain ocular integrity, and limit corneal opacification. 1,6 Many surgical techniques are used in veterinary ophthalmology to repair deep and/or melting corneal ulcers, including conjunctival pedicle grafts, [6][7][8][9][10] porcine bioscaffolding matrixes, 7,[11][12][13][14][15][16] amniotic membrane transplantation, 17,18 bovine pericardium, 19 and heterologous keratoplasty. [20][21][22] Bioscaffolding matrixes include porcine small intestinal submucosa (Vetrix ® BioSIS) and porcine urinary bladder submucosa (ACell ® ); both materials have been successfully used to repair corneal defects in dogs, cats, and horses.…”

“…[20][21][22] Bioscaffolding matrixes include porcine small intestinal submucosa (Vetrix ® BioSIS) and porcine urinary bladder submucosa (ACell ® ); both materials have been successfully used to repair corneal defects in dogs, cats, and horses. 7,[11][12][13][14][15][16] Corneoconjunctival transposition (CCT) utilizes autologous cornea and conjunctiva advanced into the ulcer bed for treatment of deep corneal ulcers. 1,23 This surgical technique has been used successfully in conjunction with keratectomy for corneal sequestra in cats and allows for a clearer visual axis compared to conjunctival pedicle grafts.…”

Evaluation of equine (Equus cabbalus) corneal endothelium stored in EUSOL-C® preservation medium

“…Unfortunately, this is different in veterinary medicine, especially in equine species, where most transplants have tectonic purposes due to the inaccessibility of viable fresh tissue (Plumer, 2009;Cichocki et al, 2016). If just the maintenance of the eye bulb is taken into account, the reported success rate of total corneal transplantation in equine species is around 89.6% (Brooks et al, 2008;Cichocki et al, 2016).…”

“…Unfortunately, this is different in veterinary medicine, especially in equine species, where most transplants have tectonic purposes due to the inaccessibility of viable fresh tissue (Plumer, 2009;Cichocki et al, 2016). If just the maintenance of the eye bulb is taken into account, the reported success rate of total corneal transplantation in equine species is around 89.6% (Brooks et al, 2008;Cichocki et al, 2016). Plumer (2009) state that the surgical techniques for total corneal or posterior lamellar transplantation are well established in equine species; however, most transplants do not result in the return of visual acuity, due to the predominant use of cryopreserved corneal buttons.…”