Modified Solubility of Etodolac through Solid Dispersion and Complexation

Abstract

Solubility and dissolution is an essential requirement for any drug to perform well in vivo. The present research was undertaken to enhance the dissolution rate of poor water soluble drug Etodolac through solid dispersion and complexation technique. Fusion method and kneading methods were employed for solubility enhancement by Solid Dispersion technique and complexation technique respectively. PEG-6000, HPMC K4M, β-Cyclodextrin and PVPK-30 are used as carriers. Physical mixtures were prepared in different ratio of drug and carriers. The prepared blends were evaluated for solubility, drug content, percent yield and drug release. Solubility enhancement was observed for all the experimental mixtures having maximum attainment for polymers PEG 6000 and PVPK-30. Pre and post enhancement Etodolac solubility values confirm the successful modification in solubility of drug through solid dispersion technique and complexation technique with slight edge toward complexation technique.