Pharmaceutical field is widely focusing on solubility parameter models to select solvent or non-solvent that can enhance solvency of drug. Solubility Parameter is very useful concept in understanding the mechanism of solvent and solvency behavior with their applications in pharmaceuticals to open the door of research having focus on theoretical considerations of solubility. Hildebrand and Hansen Solubility Parameter are frequently used to identify solvents.

Solubility and dissolution is an essential requirement for any drug to perform well in vivo. The present research was undertaken to enhance the dissolution rate of poor water soluble drug Etodolac through solid dispersion and complexation technique. Fusion method and kneading methods were employed for solubility enhancement by Solid Dispersion technique and complexation technique respectively. PEG-6000, HPMC K4M, β-Cyclodextrin and PVPK-30 are used as carriers. Physical mixtures were prepared in different ratio of drug and carriers. The prepared blends were evaluated for solubility, drug content, percent yield and drug release. Solubility enhancement was observed for all the experimental mixtures having maximum attainment for polymers PEG 6000 and PVPK-30. Pre and post enhancement Etodolac solubility values confirm the successful modification in solubility of drug through solid dispersion technique and complexation technique with slight edge toward complexation technique.

The latest tools of genomics and chemistry and applies them to target and drug discovery is chemogenomoics. It is defined as the analysis of class of organic compound libraries against families of functionally related proteins called as receptor. chemogenomoics help to investigate biological target for the new drug entities. This deals with the systematic investigation of chemical-biological interactions. Study of chemogenomoics is the very important tool in medicinal chemistry for the development of new chemical entities) The main goal of chemogenomics is to identify the newer drugs and the targets because of number of chemical entities ware present so it is very difficult to identify the targets of said chemical compounds. The chemogenomic approach is the interaction of possible drug molecules with all probable targets In this regards we have reported significance and application of chemogenomoics.

A simple, rapid, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Etodolac was developed and validated according to ICH guidelines. The quantification of the drug was carried using photodiode array detector. RP-C18 column was used in isocratic mode, with 60:40 ratio of Acetonitrile: Methanol as a mobile phase. The flow rate was set to 1.0 ml/min. The UV detection was carried out at wavelength 226 nm wavelength was selected for analysis. The method was validated by performing recovery study.

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