Lipids have wide range of applications in food and pharmaceuticals. The pharmaceuticals application of lipid is to improve solubility of drug also helps to improve the bioavailability. The dissolution/dissolving phase, which is probably the rate-limiting component for oral absorption of poorly water-soluble drugs, is eliminated by pre-dissolving pharmaceuticals in lipids, surfactants, or combinations of lipid excipients and surfactants. The most widely used co-solvents, together with lipid excipients, are propylene glycol, glycerol, and polyethylene glycols-400, poloxamer etc. various technologies are used such as melt extrusion, melt granulation for preparation of lipid based oral modified released dosage forms.  This review summaries the overview of the lipid excipients in terms of their classification, methods of absorption, and lipid-based product development. The manufacture of solid and semi-solid lipid formulations using various methodologies, applications, phase behaviour, and the regulatory outlook of lipid excipients are covered. Keywords: Solid lipids, lipid classification, solidification techniques, modified released.

Solubility and dissolution is an essential requirement for any drug to perform well in vivo. The present research was undertaken to enhance the dissolution rate of poor water soluble drug Etodolac through solid dispersion and complexation technique. Fusion method and kneading methods were employed for solubility enhancement by Solid Dispersion technique and complexation technique respectively. PEG-6000, HPMC K4M, β-Cyclodextrin and PVPK-30 are used as carriers. Physical mixtures were prepared in different ratio of drug and carriers. The prepared blends were evaluated for solubility, drug content, percent yield and drug release. Solubility enhancement was observed for all the experimental mixtures having maximum attainment for polymers PEG 6000 and PVPK-30. Pre and post enhancement Etodolac solubility values confirm the successful modification in solubility of drug through solid dispersion technique and complexation technique with slight edge toward complexation technique.