Modified vibrating-mesh nozzles for advanced spray-drying applications

Beck-Broichsitter, Moritz; Paulus, Ilka E.; Greiner, Andreas; Kissel, Thomas

doi:10.1016/j.ejpb.2015.03.001

Cited by 38 publications

(24 citation statements)

References 37 publications

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“…However, a deeper understanding of the interplay of formulation variables (Tables 1 and 2, Figure 1) and spraydrying conditions (Tables 3 and 4, Supplementary material, Figure S1) is crucial for the fabrication of specified particulate drug carriers. In this respect, the physicochemical properties of the feed solution (Table 1) affected the final product (Table 2) [ 13,14,16,17,19,22]. As an example, Fontana et al found a direct correlation between the formulation viscosity (solid content) and the size of dexamethasone-loaded poly(caprolactone) particles prepared by vibrational spray-drying [12].…”

Section: Discussionmentioning

confidence: 97%

“…14 viscosity resulted in a lower throughput rate through the vibrating nozzle (Hagen-Pouseuille's law) [16,22]. Consequently, a decreased portion of liquid volume is delivered during nozzle movement resulting in the formation of smaller particles (Table 2, Figure 1).…”

Section: Accepted Manuscriptmentioning

confidence: 96%

“…Absorption of samples was assayed at a wavelength of 300 nm [17,22,29,30]. Sildenafil concentrations were then calculated using a calibration curve (R 2 ≥0.998).…”

Section: In Vitromentioning

confidence: 99%

“…A limitation of "original" vibrational spray-drying is related to the numerous parameters influencing the properties of the final product [7, [13][14][15][16][17][18][19][20][21], causing timeconsuming investigations in order to prepare specified formulations meeting the requirements for the intended application [3,4]. Moreover, analysis of recent reports accented rather "heterogeneous" particle sizes and size distributions of obtained powder formulations [7- 11,13,[15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 98%

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Direct fractionation of spray-dried polymeric microparticles by inertial impaction

2015

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Section: Discussionmentioning

confidence: 97%

Section: Accepted Manuscriptmentioning

confidence: 96%

“…Absorption of samples was assayed at a wavelength of 300 nm [17,22,29,30]. Sildenafil concentrations were then calculated using a calibration curve (R 2 ≥0.998).…”

Section: In Vitromentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Direct fractionation of spray-dried polymeric microparticles by inertial impaction

2015

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“…Spray-drying is known to be a convenient one-step process for the continuous conversion of liquid formulations into dry particulates, which is well-established in many relevant branches such as the chemical, food or pharmaceutical industry, due to the high fl exibility to manipulate particle properties (e.g. size and morphology) 8 . It results in powders with good quality, low water activity, easier handling and storage 9, 10 .…”

mentioning

confidence: 99%

Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends

Ozsagiroglu

Güvenilir

2015

Polish Journal of Chemical Technology

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The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation effi ciency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 μm particle size with 0.512 m 2 /g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profi les are fi tted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer-Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid.

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A 3‐D numerical heat and mass transfer model for simulating the vibration effects on drying process

Rzig

Khedher

Nasrallah

2017

Heat Trans. Asian Res.

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The high‐energy costs in the drying process highlight the employment of vibration which is a promising way to intensify this process. This work presents a three‐dimensional (3‐D) numerical version that exhibits the coupled heat and mass transfer phenomena posed by the external vibrating flow of hot air during the drying process. In order to simulate 3‐D vibrating drying, a 3‐D unstructured control volume finite element method is developed to analyze the heat and mass transfer during unsaturated porous media drying. Numerical simulation results, which depict the effects of the external vibrating flow which forces the drying process to occur more rapidly and intensively than ever before, are presented and analyzed.

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Modified vibrating-mesh nozzles for advanced spray-drying applications

Cited by 38 publications

References 37 publications

Direct fractionation of spray-dried polymeric microparticles by inertial impaction

Direct fractionation of spray-dried polymeric microparticles by inertial impaction

Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends

A 3‐D numerical heat and mass transfer model for simulating the vibration effects on drying process

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