Modulation of antioxidant enzymes activities and lipid peroxidation products in diet-induced hypercholesterolemic rats fed ortanique peel polymethoxylated flavones extract

Abstract

The primary aim of this study was to investigate the effects of ortanique peel polymethoxylated flavones extract (PMF ort ) on antioxidant enzymes activities and lipid peroxide levels in organs of hypercholesterolemic and normal rats. Thirty Sprague-Dawley rats were fed high cholesterol diets supplemented with 1.5% PMF ort and niacin respectively for 49 days. Hypercholesterolemic rats fed PMF ort had significant reductions in malondialdehyde levels in the liver and brain compared to untreated hypercholesterolemic control rats. This reduction also occurred in the brain of the rats fed niacin. The activities of catalase, glutathione reductase, transferase and peroxidase were significantly reduced in the spleen, brain and liver of hypercholesterolemic rats fed PMF ort compared to control. The activities of these enzymes were only reduced in the brain and liver of rats fed niacin. The results would suggest that PMF ort modulates hypercholesterolemia-associated organ injury and oxidative stress in rat organs. PMF ort could therefore be a suitable candidate of natural origin for prophylactic and therapeutic treatment of hypercholesterolemia-associated oxidative stress and organ injury.

Antioxidative mechanism in the course of varicose veins

“…16 Oxidative stress is observed due to the increased ROS generation and the augmentation of antioxidant defense mechanisms impairment. 9 In the light of the world literature, oxidative stress is examined primarily by measuring the concentration of malondialdehyde (MDA), estimating the degree of lipid peroxidation. 2,[17][18][19][20] All the reports have shown elevated levels of MDA in the VV wall and in the plasma of patients with VV.…”

“…8 Imbalance between ROS generation and antioxidant system mechanism is called oxidative stress. 9 Aerobic organisms have developed an integrated antioxidant defense system, which consists of enzymatic (e.g. superoxide dismutase, SOD) and non-enzymatic antioxidants (e.g.…”

Comparative Study Between Lemon Peel Extract and Testosterone Supplementation on the Hippocampus of Orchiectomized Rat

“…Also, citrus contains antioxidative compounds such as flavonoids (Green et al, 2011), which act by neutralizing the oxidizing free radicals (Abdel Moneim, 2014). Moreover, Okuyama et al (2016) stated that auraptene (AUR), citrus peel component, exerted suppressive effects on astrocyte activation and neuronal cell death in the brain of a lipopolysaccharide -injected inflammation model.…”

Oxidative stress biomarkers in organs of hyperlipidaemic and normal rats fed tropical red seaweed, Gracilaria changii

“…The decrease in antioxidant enzyme activities in organs has been associated with oxidative stress (Montilla et al 2006;Bouderbala et al 2008;Green et al 2012). In the current study, although feeding a high-cholesterol/fat diet alone did not show a significant difference in rat kidney MDA levels, it significantly reduced the antioxidant enzyme activity as compared to normal rats.…”