Modulation of estrogen-induced peroxidase activity in the rat uterus by thyroid hormones

Keeping, Hugh S.; Newcombe, Anne-Marie; Jellinck, Peter H.

doi:10.1016/0022-4731(82)90142-x

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…Additionally, hypothyroidism reduces the weight of the uterus in rats (40) as well as the number and force of the uterine contractions in bitches (11) and rats (5)(6). In rodents, hypothyroidism increases the concentration of estrogen receptors (41) and reduces the concentrations of sialic acid and glycogen (42) in the uterus. Likewise, it affects the proliferative activity, apoptosis, and vascularization of the placenta (40).…”

Section: Discussionmentioning

confidence: 99%

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

et al. 2016

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“…In previous work, we have shown that the induction of peroxidase in immature rat uteri by estrogens could be influenced by treating the animals with thyroid hormones (20), progesterone (10). or the catechol estrogen, 2-hydroxyestradiol (2 1).…”

Section: Discussionmentioning

confidence: 99%

Estrogen–androgeri interaction: selective inhibition of estrogen-induced uterine peroxidase by testosterone and 5α-dihydrotestosterone

Jellinck¹,

Affleck²,

Newcombe³

1983

Can. J. Biochem. Cell Biol.

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The effect of testosterone (T) and dihydrotestosterone (DHT) on the induction of peroxidase and glucose-6-phosphate dehydrogenase (G6PDH) in the immature rat uterus by estradiol (E2) was investigated. T (0.5-12.5 mg/rat) given on 3 successive days produced a large increase in uterine weight but, in contrast to E2, did not induce peroxidase or significantly augment uterine G6PDH. However, this androgen, even at a very low dose (50 micrograms/rat three times), inhibited the induction of peroxidase without a corresponding effect on G6PDH when given concurrently with E2 and was more effective than DHT. Inhibition by androgen was also observed when diethylstilbestrol was used to stimulate uterine growth. Combined treatment with E2 (3 micrograms/rat) and T (3 mg/rat) produced a cytosolic and nuclear estrogen receptor pattern in the uterus similar to that observed with E2 alone after various time intervals. The results speak against a direct inhibitory action or T on E2-induced uterine peroxidase via the estrogen receptor and confirm the lack of aromatization of T to E2 in the immature rat. Possible mechanisms for modifying the action of estrogens by androgens are discussed, particularly in the light of E2-induced eosinophilia. It is proposed that steroid hormones can interact in several ways and that uterine peroxidase provides a useful indicator to study steroid hormone action.

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“…In the rat experiment, thyroid hormone regulates the response of the uterus to estrogen, mainly by modulating uterine estrogen receptor expression and uterine estrogen-induced peroxidase activity. 32 Thyroid dysfunction leads to menstrual and ovulatory disturbances. 33 Overt hypothyroidism increases peripheral aromatization, decreases sex hormone-binding globulin, decreases estradiol concentrations, and increases unbound fraction form.…”

Section: Third What Can Explain the Relationship Between Uterine Broids And Hypothyroidism?mentioning

confidence: 99%

Association between Uterine Fibroid and Benign Thyroid Disease: Nationwide Population-Based Cohort Study

Yuk

Kim

2021

Preprint

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Background Uterine fibroid and benign thyroid disease are common diseases in women. Objective This study aims to evaluate both diseases are related. Study Design: We established the uterine fibroid group according to diagnosis codes and surgery codes using the Korea National Health Insurance data from 2007 to 2020. All women from 20 to 50 years old with uterine myomectomy from 2007 to 2020 were identified (uterine fibroids group). For controls, 1:1 propensity score matching was performed on age at 5-year intervals, socio-economic status (SES), region, Charlson comorbidity index (CCI), and menopause (control group). Thyroid disease cases were selected using the thyroid disease diagnosis code and thyroid-associated laboratory examination. Results A total of 21,246 patients were extracted from the uterine fibroid and control groups, respectively. The median ages of each group were 40 (range, 35 ~ 44) years and 40 (range, 35 ~ 44) years old. Benign thyroid disease was 469 (2.2%) in the uterine fibroid group and 246 (1.2%) in the control group. Among benign thyroid diseases, hypothyroidism was the largest in both groups. A non-toxic single thyroid nodule followed it. The uterine fibroid group had a higher incidence of hypothyroidism {relative risk (RR) 1.943, 95% CI 1.5-2.516), autoimmune thyroid disease (RR 1.59, 95% CI 1.065–2.373), goiter (RR 1.773, 95% CI 1.051–2.99), nontoxic single thyroid nodule (RR 2.213, 95% CI 1.685–2.907), other thyroid disease (RR 2.31, 95% CI 1.608–3.317), and total thyroid disease (RR 1.905, 95% CI 1.63–2.226) in logistic regression analysis adjusted for age, SES, region, CCI, and menopause compared than the control group. The uterine fibroid group had a higher risk of hypothyroidism (HR 1.431, 95% CI 1.023–2.001) and nontoxic single thyroid nodule (HR 1.511, 95% CI) in cox regression adjusted for age, SES, region, CCI, and menopause. Conclusions Uterine fibroid might be associated with hypothyroidism and thyroid nodule.

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Modulation of estrogen-induced peroxidase activity in the rat uterus by thyroid hormones

Cited by 9 publications

References 21 publications

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

Estrogen–androgeri interaction: selective inhibition of estrogen-induced uterine peroxidase by testosterone and 5α-dihydrotestosterone

Association between Uterine Fibroid and Benign Thyroid Disease: Nationwide Population-Based Cohort Study

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