Modulation of insulin secretion by pancreatic ganglionic nicotinic receptors

Stagner, J. I.; Samols, E.

doi:10.2337/diabetes.35.8.849

Cited by 16 publications

(9 citation statements)

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“…The effects of ganglionic pre-and postsynaptic nAChRs antagonism were studied in the in vitro canine pancreas. Results suggest that nAChRs are present at the ganglionic level in the pancreas and modulate insulin secretion by a complex intraganglionic mechanism [29] . Direct evidence of the presence of nicotinic receptors on islet beta-cells has also been obtained [28] .…”

Section: Nicotine On Islet Beta-cellsmentioning

confidence: 99%

Impact of cigarette smoking in type 2 diabetes development

et al. 2009

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Many patients with type 2 diabetes mellitus (DM2) are at risk for micro and macro vascular complications, which could be observed in heavy smokers. Cigarette smoking increases the risk for type 2 diabetes incidence. Nicotine, acknowledged as the major pharmacologically active chemical in tobacco, is responsible for the association between cigarette smoking and development of diabetes. This minireview summarized recent studies on nicotine effects on insulin action and insulin secretion, indicating the impact of nicotine on type 2 diabetes development.

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Section: Nicotine On Islet Beta-cellsmentioning

confidence: 99%

Impact of cigarette smoking in type 2 diabetes development

et al. 2009

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“…As has, however, been shown in the perfused canine pancreas, ganglionic transmission could be more complex than simply involving nicotinic mechanisms. Possibly several other transmission pathways are also involved [16], but this has not been explored in great detail.…”

Section: Parasympathetic Nervesmentioning

confidence: 99%

Autonomic regulation of islet hormone secretion - Implications for health and disease

2000

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“…Postganglionic sympathetic nerves terminate in the pancreas and release the neurotransmitter noradrenaline which acts via α or β receptors to produce either inhibitory or stimulatory effects on pancreatic function (Stagner & Samols, 1986 ;Dunning et al 1991). In addition to these classical neurotransmitters and their coexisting neuropeptides, peptidergic neurons containing the neuropeptides VIP (Larsson et al 1978 ;Sundler et al 1978 ;Bishop et al 1980), neuropeptide Y (NPY) (Su et al 1987), galanin (Gal) (Lindskog et al 1991 ;McDonald et al 1992) and the neurotransmitter nitric oxide (Ekblad et al 1994 ;De Giorgio et al 1992) have also been identified in the pancreatic parenchyma of various species ; they are believed to interact with the neurotransmitters acetylcholine and noradrenaline in regulating islet secretion (see review by Brunicardi et al 1995).…”

Section: mentioning

confidence: 99%

Peptidergic hormones and neuropeptides, and aminergic neurotransmitters of the pancreatic islets of the Houbara bustard (Chlamydotis undulata)

et al. 2000

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Immunoreactivity to insulin (Ins), somatostatin (Som), glucagon (Glu) and pancreatic polypeptide (PP) was found in 70 %, 22 %, 15 % and 11 % respectively of Houbara pancreatic endocrine islet cells. Whilst Ins occurred centrally and SOM was observed both in peripherally and centrally located islets, the other hormones were localised in peripheral islet cells ; Som was also observed in neuronal cell bodies and nerve fibres. In addition, the islet cells contained substance P (SP) (65 %) in the centre and vasoactive intestinal polypeptide (VIP) (2 %) at the periphery. Immunoreactivity to choline acetyltransferase (ChAT), VIP and galanin (Gal) occurred in the walls of blood vessels located mainly at the periphery of islets. Occasionally, VIP and Gal immunoreactive varicose nerve terminals and ChAT immunoreactive cell bodies were also observed in the centre of islets. SP neuronal cell bodies were not observed but prominent SP immunoreactive varicose terminals were discernible in capillary walls within the islets. Neuropeptide Y (NPY) immunoreactive neurons were detected in neuronal cell bodies located mainly peripherally. Neuronal nitric oxide synthase (nNOS) immunoreactivity occurred in neuronal cell bodies and nerve fibres mainly at the periphery and also in centrally located islet endocrine cells. Immunoreactivity to tyrosine hydroxylase (TH) was similar in distribution to that of ChAT. In comparison with other avian species, the islets of the dorsal pancreatic lobe of the bustard contain all the peptidergic hormones normally present in the islets of other avian species, but are not segregated into dark A and light B cells. Many of the insulin containing cells also contained SP. The islets also contained several neuropeptides which are probably involved in their regulation.

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Modulation of insulin secretion by pancreatic ganglionic nicotinic receptors

Cited by 16 publications

References 0 publications

Impact of cigarette smoking in type 2 diabetes development

Impact of cigarette smoking in type 2 diabetes development

Autonomic regulation of islet hormone secretion - Implications for health and disease

Peptidergic hormones and neuropeptides, and aminergic neurotransmitters of the pancreatic islets of the Houbara bustard (Chlamydotis undulata)

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