Modulation of long-term memory by delayed administration of the amide of L-pyroglutamyl-D-alanine, a nootropic agent, in spaced and massed training in rats

Vysotskii, A. L.; Vysotskii, D. L.; Gudasheva, T. A.; Ostrovskaya, R. U.; Анохин, К. В.

doi:10.1007/bf02465317

Cited by 2 publications

(2 citation statements)

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“…These properties of noopept may well contribute towards restoration of spatial memory impaired by bulbectomy. Noopepts ability to attenuate the OB-induced deficit of spatial memory in the water maze is consistent with its positive effect on another model of contextual-dependant behaviour, conditioned freezing (Vysotskii et al, 1999).…”

Section: Restorative Effect Of Noopept On Spatial Memory Impairment Imentioning

confidence: 66%

The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model

et al. 2006

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The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy. We have shown previously that these animals developed Alzheimer's disease (AD)-like behaviour, morphology and biochemistry including impairment of spatial memory, regional neuronal degeneration and elevated Abeta peptide brain levels. In the current investigation, spatial memory was assessed using the Morris water maze and serum antibodies to in vitro morphologically characterized amyloid structures of both Abeta((25-35)) peptide and equine lysozyme, as well as to neurotrophic glial factor S100b, were analyzed by enzyme-linked immunosorbent assay (ELISA). Noopept (administered at a dose of 0.01 mg/kg for a period of 21 days and during a further 5 days training) restored spatial memory and increased serum antibody levels to oligomers of Abeta((25-35)) peptide but not to equine lysozyme amyloid or S100b protein in bulbectomized animals. The positive immunotropic effect of noopept to Abeta((25-35)) peptide prefibrillar aggregates was more marked in sham-operated compared to the bulbectomized subjects which were characterized by an overall suppression of immunoreactivity. Enhancement of the immune response to Abeta((25-35)) peptide prefibrils caused by noopept may attenuate the neurotoxic consequences of amyloid fibrillization and also be associated with an improvement in spatial memory in bulbectomized mice. These actions of noopept, combined with its previously reported neuroprotective and cholinomimetic properties, suggests that this dipeptide may well be useful for improving cognitive deficits induced by neurodegenerative diseases.

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Section: Restorative Effect Of Noopept On Spatial Memory Impairment Imentioning

confidence: 66%

The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model

et al. 2006

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“…Российские исследователи внесли значительный вклад в изучение молекулярно-физиологических эффектов этого нейротропного дипептида. Пироглутамил-аланин в дозе 0,5 мг/кг (внутрибрюшинно) показал достоверное улучшение долговременной памяти в экспериментах по изучению контекстной памяти и условных рефлексов [41]. Пироглутамилаланин значительно увеличивал выживаемость животных после двусторонней окклюзии общих сонных артерий [42], снижал гиперактивность в тесте «открытое поле», устранял нарушение способности к обучению и улучшал память [43], восстанавливал долгосрочное потенцирование гиппокампа после повреждения алкоголем [44].…”

Section: пироглутаматсодержащие пептидыunclassified