Modulation of Pharmacokinetics by Molecular Manipulation

Ariëns, E. J.

doi:10.1016/b978-0-12-060302-2.50008-7

Cited by 37 publications

(7 citation statements)

References 157 publications

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“…In small agonist molecules, a differentiation is usually difficult to see between the groups in the molecule primarily involved in the receptor binding, the haptophore, and the groups primarily involved in the receptor activation, the actophore. Groups, especially those involved in pharmacon metabolism and pharmacon transport, are more easily recognizable (Ariens and Simonis, 1974;Ariens, 1971b). In larger bioactive molecules, especially polypeptides, programming for various aspects of the function may be localized in different amino acid sequences, as shown schematically in Fig.…”

Section: Structure and Actionmentioning

confidence: 99%

The Pharmacon-Receptor-Effector Concept

Ariëns

Beld

Miranda

et al. 1979

General Principles and Procedures

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Section: Structure and Actionmentioning

confidence: 99%

The Pharmacon-Receptor-Effector Concept

Ariëns

Beld

Miranda

et al. 1979

General Principles and Procedures

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“…79,80 They were, therefore, (unsuccessfully) tested for the treatment of malignant melanoma. 82 Similar efforts were made to fi nd selective cancer chemotherapeutics, and a variety of drugs that are known to accumulate selectively in particular tissues have also been tried. 82 Similar efforts were made to fi nd selective cancer chemotherapeutics, and a variety of drugs that are known to accumulate selectively in particular tissues have also been tried.…”

Section: Site-directed Drug Deliverymentioning

confidence: 99%

Designing Prodrugs and Bioprecursors

Wermuth¹

2008

The Practice of Medicinal Chemistry

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“…First, since medicinal chemists are becoming more sensitive to the fact that optimal drug design must take into account Albert, 1973Ariens, 1966Ariens, 1971Palor, 1982Bundgaard, 1982Digenis and Swintosky, 1975Harper, 1959Harper, 1962Higuchi and Stella, 1975Roche, 1977Sinkula and Yalkowsky, 1975Sinkula, 1975Stella, 1973Stella, 1977Stella and Himmelstein, 1980Yalkowsky and Morozowich, 1980 the physical/chemical form of the drug as it pertains to stability, solubility, and other formulation factors, as well as pharmacokinetic factors, such as the transport properties of the drug, it is quite likely that the prodrug approach to optimizing those properties will become an integral part of basic drug design. As such, there is likely to be fewer examples where prodrugs will have to be used in a hindsighted manner to solve problems.…”

Section: Acknowledgementmentioning

confidence: 99%

Directed Drug Delivery

Borchardt¹,

Repta²,

Stella³

1985

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. PREFACEThis book is based on the proceedings of the symposium entitled "Directed Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the symposium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system requires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disciplines in identifying the problems and approaches for the development of a rational and effective drug delivery system. Thus the information provided herein will be of value not only to the pharmaceutical chemists who are responsible for dosage form design, but also to the pharmacokineticists, pharmacologists, and clinicians involved in biological evaluation of drug delivery systems. The volume should also be of interest to the analytical chemists who must provide technology to quantitcltively evaluate drug delivery. Additionally, this work will also interest the biochemists and medicinal chemists involved in drug discovery, since the drug delivery system often plays a major role in determining the success or failure of a new drug entity.Each speaker at the symposium was requested to contribute a chapter reviewing the contribution of their major discipline to the development of a successful drug delivery system. Topics covered in this volume include pharmacokinetics and pharmacodynamic factors (Section A) and physiological and biochemical factors (Section B) that influence directed drug delivery, various approaches to controlled and targeted drug delivery, including physical (SectionC) and biological (Section D) systems, as well as appropriate and important analytical chemistry topics (Section E).The individual chapters in this volume represent comprehensive, up-to-date reviews of the subject material. However, to gain maximum appreciation for the multidisciplinary nature of drug delivery, the editors suggest a thorough reading of the entire volume.

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Modulation of Pharmacokinetics by Molecular Manipulation

Cited by 37 publications

References 157 publications

The Pharmacon-Receptor-Effector Concept

The Pharmacon-Receptor-Effector Concept

Designing Prodrugs and Bioprecursors

Directed Drug Delivery

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